Prograf

(tacrolimus)

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Prevents rejection of a transplanted organ.

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Our bottom line

Prograf (tacrolimus) is a good medicine that prevents rejection of an organ transplant, but you will need to be on it lifelong.

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  • Lowest price with coupon
    $449.59
Quick facts about Prograf
  • Drug class: Transplant
  • Rx status: Prescription only
  • Generic status: Lower-cost generic available (tacrolimus)

Upsides

  • Prevents your body from rejecting a transplanted organ.
  • Available as an extended-release pill, so it can be taken just once daily.
  • Less cosmetic side-effects than other anti-rejection medicine like cyclosporine.
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What to expect from Prograf, on one page

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Downsides

  • Regular blood tests are required for monitoring while on Prograf (tacrolimus).
  • Can cause a lot of side-effects, such as high blood sugar, high blood pressure, mental status changes, and kidney damage, especially with lifelong use.
  • Increases your risk of infection and certain cancers.
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What to expect from Prograf, on one page

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How it works

Prograf (tacrolimus) is an immunosuppresant that lowers the activity of your immune system, so it doesn't attack the transplanted organ.

Quick facts about Prograf
  • Drug class: Transplant
  • Rx status: Prescription only
  • Generic status: Lower-cost generic available (tacrolimus)

Used for

  • Prevention of heart transplant rejection
  • Prevention of liver transplant rejection
  • Prevention of kidney transplant rejection

Dosage forms

  • Pill
  • Extended release
  • Injection
Tried Prograf? Write a review!

Prices and coupons

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What to expect when you take Prograf (tacrolimus) for Transplant rejection prevention

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  • First few hoursHours
    First few daysDays
    First few weeksWeeks
    First few monthsMonths
  • Effectiveness
  • Starts to kick in
    Full effects
  • First few hoursHours
    First few daysDays
    First few weeksWeeks
    First few monthsMonths
  • Possible side effects
  • Tremor
  • Insomnia
  • Infection
  • Swelling in arms and legs
  • Diarrhea
  • Headache
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Side effect rates for Prograf (tacrolimus)

From 157 clinical trials of Prograf when taken for heart transplant (taken with azathioprine and corticosteroids)
  • High blood pressure
    62%62%
  • Kidney Function Abnormal
    56%56%
  • Anemia
    50%50%
  • Low white blood cells
    48%48%
  • Viral infection
    32%32%
  • Diabetes Mellitus
    26%26%
  • Infection
    24%24%
  • High blood sugar
    23%23%
  • High cholesterol
    18%18%
  • Bronchitis
    17%17%
  • Urinary Tract Infection
    16%16%
  • Fluid around the heart
    15%15%
  • Tremor
    15%15%
0%
10%
20%
30%
40%
50%
60%
70%
80%
Where we got our data »

The placebo bar shows how common a side effect was for people taking a sugar pill instead of Prograf.

Prograf (tacrolimus)
Placebo

People taking Prograf felt side effect more

People taking Prograf felt side effect less

No difference

Risks and Warnings for Prograf (tacrolimus)

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    • Higher risk if:
    • Taking other immunosuppressant drugs
    • Age 60 or older
    • Weak immune system

    Prograf (tacrolimus) works by lowering your immune response, so it increases your risk of bacterial, fungal, or viral infections.

    This is a black box warning. The FDA requires this warning when there is a significant risk of serious or life-threatening effects that anyone taking the drug should consider.

Means that some groups have a high risk of experiencing this side effect

Common concerns from people taking Prograf (tacrolimus)

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Kidneys and liver
  • Prograf (tacrolimus) can cause kidney damage, especially in patients with poor kidney function, or who are taking other drugs that can damage the kidneys. Your doctor will order blood tests to check your kidney function and Prograf (tacrolimus) levels, and will change your dose if needed.
  • Can cause a lot of side-effects, such as high blood sugar, high blood pressure, mental status changes, and kidney damage, especially with lifelong use.