Prolia

(Denosumab)

3.6/ 5 average rating with 15 reviewsforProlia
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Prevents bone loss.

Skip Upsides & Downsides section. Skip to side effects section.

Our bottom line

Prolia (Denosumab) is an effective and convenient treatment for osteoporosis if other options haven’t worked or aren’t appropriate for you. There’re risks of some rare side effects, so make sure you're following up with your doctor regularly.

Lowest price near you
  • Lowest price with coupon
    $2210.25
Quick facts about Prolia
  • Drug class: Musculoskeletal
  • Rx status: Prescription only
  • Generic status: No lower cost generic available

Upsides

  • Prolia (Denosumab) is effective at preventing bone loss, making your bones stronger and lowering your chance of getting a fracture.
  • Only need to get an injection every 6 months, so you don’t have to remember to take something every day.
People’s experience with Prolia

15reviews so far. What do you think?

Downsides

  • Approved for women only after they’ve reached menopause. Don’t use this if you’re pregnant or planning to become pregnant.
  • Can lower blood calcium levels. You might need to take calcium supplements to prevent this.
  • Not available as a generic.
How it works

Prolia (Denosumab) is a monoclonal antibody. It blocks a protein that sends signals to break down your bones, and therefore prevents bone loss.

Quick facts about Prolia
  • Drug class: Musculoskeletal
  • Rx status: Prescription only
  • Generic status: No lower cost generic available

Dosage forms

  • Injection
People’s experience with Prolia

15reviews so far. What do you think?

Prices and coupons

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Side effect rates for Prolia (Denosumab)

From 7762 clinical trials of Prolia when taken for osteoporosis in postmenopausal women (60 mg)
  • Back pain
    35%35%
    35%35%
  • Pain in extremity
    12%12%
    11%11%
  • Musculoskeletal pain
    8%8%
    8%8%
  • Hypercholesterolemia
    7%7%
    6%6%
  • Cystitis
    6%6%
    6%6%
  • Vertigo
    5%5%
    5%5%
  • Edema peripheral
    5%5%
    4%4%
  • Upper respiratory tract infection
    5%5%
    4%4%
  • Sciatica
    5%5%
    4%4%
  • Pneumonia
    4%4%
    4%4%
  • Bone pain
    4%4%
    3%3%
  • Anemia
    3%3%
    3%3%
  • Angina pectoris
    3%3%
    2%2%
  • Abdominal pain upper
    3%3%
    3%3%
  • Myalgia
    3%3%
    2%2%
  • Insomnia
    3%3%
    3%3%
  • Rash
    3%3%
    2%2%
  • Atrial fibrillation
    2%2%
    2%2%
  • Flatulence
    2%2%
    1%1%
  • Gastroesophageal reflux disease
    2%2%
    2%2%
  • Asthenia
    2%2%
    2%2%
  • Pharyngitis
    2%2%
    2%2%
  • Herpes zoster
    2%2%
    2%2%
  • Spinal osteoarthritis
    2%2%
    2%2%
  • Pruritus
    2%2%
    2%2%
  • Mortality
    2%2%
    2%2%
  • Adverse events
    2%2%
    2%2%
0%
10%
20%
30%
40%
50%
60%
70%
80%
Where we got our data »

The placebo bar shows how common a side effect was for people taking a sugar pill instead of Prolia.

Prolia (Denosumab)
Placebo

People taking Prolia felt side effect more

People taking Prolia felt side effect less

No difference

Risks and Warnings for Prolia (Denosumab)

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    • Higher risk if:
    • Taking steroids

    Some people who take Prolia (Denosumab) have had unusual thigh fractures. However, it’s unclear if Prolia (Denosumab) causes these fractures. Report any unusual hip, thigh, or groin pain to your doctor.

Common concerns from people taking Prolia (Denosumab)

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Pregnancy

Research studies with real people or animals found harmful effects on unborn babies. If you’re pregnant, the risks to your unborn baby outweigh the benefits.

Tip: Always talk with your doctor before you take any medication while pregnant.
FDA pregnancy category for Prolia
XUnsafe
Price
  • Not worth it
    Low hassle
    Reviewed Proliaon 6/3/2017The price kept going up until I could no longer afford it.
    71
    Woman
    Two years or more
    Postmenopausal osteoporosis
Pain
  • Can cause skin irritation, joint pain, limb pain, and back pain.
  • Not worth it
    Big hassle
    Reviewed Proliaon 8/8/2017wish I never had gotten the shot, in terrible pain now for over a month, no energy, lousy sleep, no appetite, worst I ever felt
    79
    Woman
    A month or so
    Osteoporosis
  • Not worth it
    Reviewed Proliaon 7/17/2017The pain is unbearable at times. It's been 4 mon.ths with no improvement.
    67
    Woman
    A year or so
    Postmenopausal osteoporosis
  • Not worth it
    Big hassle
    Reviewed Proliaon 6/10/2017Severe back pain, hospitalization for the side effects that have lasted now for 2 months with no improvement. Would not get this shot again.
    67
    Woman
    A year or so
    Postmenopausal osteoporosis