Prozac

(fluoxetine)

3.5/ 5 average rating with 1319 reviewsforProzac
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Improves mood and helps you relax.

Skip Upsides & Downsides section. Skip to side effects section.

Our bottom line

Prozac (fluoxetine) is good for treating depression and anxiety. It's more energizing than other antidepressants, so it may not be the best choice for people who have trouble sleeping.

Lowest price near you
  • Lowest price with coupon
    $562.08
Quick facts about Prozac
  • Drug class: Mental health
  • Rx status: Prescription only
  • Generic status: Lower-cost generic available (fluoxetine)

Upsides

  • Effectively treats a variety of mental health conditions such as depression, OCD, and panic disorder.
  • It's more energizing than other antidepressants, so it's good for people who have low energy.
  • Might be a good option for treating children with depression and/or OCD.
  • Doesn't have effects on the heart unlike other antidepressants so it may be a better treatment choice for older people.
  • Can cause a significant amount of weight loss which is an added benefit for those who are overweight or obese.
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What to expect from Prozac, on one page

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People’s experience with Prozac

1319reviews so far. What do you think?

Downsides

  • Takes at least 1 to 2 weeks to kick in and can take up to 12 weeks for maximum effect. Prozac (fluoxetine) tends to take more time to start working compared to similar alternatives.
  • Can lower your sex drive.
  • Can increase the risk of suicidal thoughts and/or behavior in those age 24 or younger.
  • You may need to try out several different antidepressants before you find the one that works for you.
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What to expect from Prozac, on one page

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How it works

Prozac (fluoxetine) is a selective serotonin reuptake inhibitor (SSRI) antidepressant. It increases serotonin activity in the brain, which regulates mood.

Quick facts about Prozac
  • Drug class: Mental health
  • Rx status: Prescription only
  • Generic status: Lower-cost generic available (fluoxetine)

Dosage forms

  • Pill
  • Delayed-release pill
  • Liquid
People’s experience with Prozac

1319reviews so far. What do you think?

Prices and coupons

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What to expect when you take Prozac (fluoxetine) for Panic Disorder

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  • First few daysDays
    First few weeksWeeks
    First few monthsMonths
    Long term
  • Effectiveness
  • Starts to kick in
    Full effects
  • First few daysDays
    First few weeksWeeks
    First few monthsMonths
    Long term
  • Possible side effects
  • Lack of energy
  • Nausea
  • Difficulty sleeping
  • Nervousness
  • Lower sex drive
  • Sleepiness
Skip side effects section. Skip to risks and warnings section.

Side effect rates for Prozac (fluoxetine)

From 717 clinical trials of Prozac when taken for bulimia
  • Inability to sleep
    33%33%
    13%13%
  • Nausea
    28%28%
    11%11%
  • Lack of energy
    21%21%
    9%9%
  • Anxiety
    15%15%
    9%9%
  • Sleepiness
    13%13%
    5%5%
  • Tremor
    13%13%
    1%1%
  • Nervousness
    11%11%
    5%5%
  • Yawn
    11%11%
  • Indigestion
    10%10%
    6%6%
  • Sore throat
    10%10%
    5%5%
  • Dry mouth
    9%9%
    6%6%
  • Flu syndrome
    8%8%
    3%3%
  • Diarrhea
    8%8%
    6%6%
  • Loss of appetite
    8%8%
    4%4%
  • Sweating
    8%8%
    3%3%
  • Impotence
    7%7%
  • Abnormal ejaculation
    7%7%
  • Sinus infection
    6%6%
    4%4%
  • Lower sex drive
    5%5%
    1%1%
  • Abnormal dreams
    5%5%
    3%3%
  • Rash
    4%4%
    4%4%
  • Widening of blood vessels
    2%2%
    1%1%
0%
10%
20%
30%
40%
50%
60%
70%
80%
Where we got our data »

The placebo bar shows how common a side effect was for people taking a sugar pill instead of Prozac.

Prozac (fluoxetine)
Placebo

People taking Prozac felt side effect more

People taking Prozac felt side effect less

No difference

Risks and Warnings for Prozac (fluoxetine)

Skip risks section. Skip to common concerns section.
    • Higher risk if:
    • Age 24 or younger

    Prozac (fluoxetine) may increase the risk of suicidal thoughts or behavior in people age 24 or younger. Prozac (fluoxetine) is not approved in children under 8 for depression or under 7 for OCD. Watch for worsening depression or any unusual changes in mood or behavior, especially during the first few months of treatment or when the dose changes. Talk to a doctor right away if you notice anxiety, irritability, aggression, or any other unusual behaviors.

    This is a black box warning. The FDA requires this warning when there is a significant risk of serious or life-threatening effects that anyone taking the drug should consider.

Means that some groups have a high risk of experiencing this side effect

Pharmacist Q&A

Prozac (fluoxetine) questions for

Frequently Asked Questions

This medication treats bulimia.

Who is this drug for?

This medication treats bulimia.

Common concerns from people taking Prozac (fluoxetine)

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Alcohol
  • Worth it
    Low hassle
    Reviewed Prozacon 8/8/2017Limit alcohol
    21
    Woman
    Two years or more
    Panic disorder
  • Worth it
    Low hassle
    Reviewed Prozacon 5/14/2017Try to take it at the exact same time each day. Never miss a day. Avoid the use of alcohol as much as possible.
    19
    Man
    A few months
    Depression
  • Worth it
    Some hassle
    Reviewed Prozacon 5/6/2017Alcohol really messes with this med.
    29
    Man
    A year or so
    Obsessive-compulsive disorder
Food
  • Worth it
    Low hassle
    Reviewed fluoxetineon 2/13/2018Take it with food to avoid nausea!
    24
    Woman
    A year or so
    Would rather not say
  • Worth it
    Some hassle
    Reviewed Prozacon 8/27/2017It helped reduce my acne. Take it with a fatty breakfast, so it won't upset your stomach.
    34
    Woman
    A month or so
    Depression
  • Worth it
    Big hassle
    Reviewed Prozacon 6/16/2017Started taking it again after a two year break for severe panic attacks and insomnia. I agained 40 pounds the last time but lost it very quickly after stopping. I'm already already starting to feel the positive results again after three weeks. I know it takes a full two months to kick in so I'm patiently waiting and I started to work out and watch my diet so I don't gain weight again. I hope the second time is as good as the first.
    42
    Man
    A few months
    Panic disorder
Pain
  • Worth it
    Some hassle
    Reviewed Prozacon 9/14/2016Caused night sweats but increased energy and decreased chronic pain issues.
    35
    Woman
    Depression
Sex
  • Worth it
    Some hassle
    Reviewed Prozacon 9/1/2017Increased libido but made orgasm impossible. Psychiatrist put me on Wellbutrin and that fixed it. Otherwise EXCELLENT. Totally knocked out my anxiety. Only downside is it made my essential tremors much, much worse so I have had to wean off it and onto something else.
    24
    Woman
    Two years or more
    Depression
  • Not worth it
    Big hassle
    Reviewed Prozacon 6/4/2017I wish I knew how much it would decrease my libido and my appetite. It also worsened my sleep and made it difficult to Even go to bed at night
    16
    Woman
    Two years or more
    Depression
  • Worth it
    Low hassle
    Reviewed Prozacon 5/2/2017Loss of libido wasn't fun, but the only side effect I have so definitely worth it.
    25
    Woman
    A month or so
    Social anxiety disorder
Sleep
  • Worth it
    Low hassle
    Reviewed ProzacTake at night. Prozac made me drowsy
    18
    Man
  • Worth it
    Some hassle
    Reviewed fluoxetineon 10/23/2017If you sleep a lot or excessively due to depression you WILL wake up. It does work but it seems to wear off after a while?
    22
    Woman
    Two years or more
    Bipolar disorder-associated depression
  • Not sure
    Some hassle
    Reviewed Prozacon 5/11/2017Not sure how it makes me feel sometimes I'm drowsy sometimes I'm hyper
    23
    Woman
    Less than a week
    PTSD
Weight
  • Prozac (fluoxetine) can cause loss of appetite and weight loss. If you notice this, talk to your doctor. You may have to change to a different medicine.
  • Can cause a significant amount of weight loss which is an added benefit for those who are overweight or obese.
  • Not sure
    Some hassle
    Reviewed fluoxetineon 3/7/2018I have gained weight since started taking it 8yrs ago so I didn't lose my appetite at all. After so long I am about to try something different as the problems with sleeping are getting worse:(
    41
    Woman
    Two years or more
    Post-traumatic stress disorder
  • Worth it
    Some hassle
    Reviewed Prozacon 5/29/2017Didn't gain weight and made me feel so much better but ruined my sex drive which is getting me down. Worth it though
    18
    Woman
    Two years or more
    Depression
  • Worth it
    Low hassle
    Reviewed Prozacon 5/10/2017Made me lose a significant amount of weight.
    18
    Woman
    Two years or more
    Depression

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