Rapamune

(sirolimus)

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Prevents rejection of a transplanted organ.

Skip Upsides & Downsides section. Skip to side effects section.

Our bottom line

Rapamune (sirolimus) is a reliable medicine that prevents rejection of an organ transplant but requires consistent monitoring.

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  • Lowest price with coupon
    $151.25
Quick facts about Rapamune
  • Drug class: Transplant
  • Rx status: Prescription only
  • Generic status: Lower-cost generic available (sirolimus)

Upsides

  • Rapamune (sirolimus) is good at preventing organ rejection.
  • Causes less harm to the kidneys with long-term use than similar medicines.
  • Fewer effects on blood sugar and blood pressure compared to other immunosuppressants.
  • Conveniently taken once daily.
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What to expect from Rapamune, on one page

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Downsides

  • You’ll need regular blood tests while taking Rapamune (sirolimus), especially when you first start the medicine.
  • Can cause high lipids (fats like cholesterol and triglycerides), especially with lifelong use. You might need to take other medicines to control your lipids while on Rapamune (sirolimus).
  • Raises your risk of infection and certain cancers.
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What to expect from Rapamune, on one page

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How it works

Rapamune (sirolimus) is an immunosuppresant that lowers your immune system activity so your body doesn't reject the transplanted organ.

Quick facts about Rapamune
  • Drug class: Transplant
  • Rx status: Prescription only
  • Generic status: Lower-cost generic available (sirolimus)

Used for

  • Prevention of kidney transplant rejection
  • Lymphangioleiomyomatosis

Dosage forms

  • Pill
  • Liquid
Tried Rapamune? Write a review!

Prices and coupons

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What to expect when you take Rapamune (sirolimus) for Prevention of kidney transplant rejection

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  • First few hoursHours
    First few daysDays
    First few weeksWeeks
    First few monthsMonths
  • Effectiveness
  • Starts to kick in
    Full effects
  • First few hoursHours
    First few daysDays
    First few weeksWeeks
    First few monthsMonths
  • Possible side effects
  • High triglycerides
  • High cholesterol
  • Swelling in arms and legs
  • Stomach pain
  • Constipation
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Side effect rates for Rapamune (sirolimus)

From 342 clinical trials of Rapamune when taken for prevention of kidney transplant rejection (2 mg)
  • Swelling in arms and legs
    54%54%
    48%48%
  • High triglycerides
    45%45%
    23%23%
  • High blood pressure
    45%45%
    48%48%
  • High cholesterol
    43%43%
    23%23%
  • Higher blood creatinine (marker of poorer kidney function)
    39%39%
    38%38%
  • Constipation
    36%36%
    31%31%
  • Headache
    34%34%
    31%31%
  • Stomach pain
    28%28%
    30%30%
  • Urinary tract infection
    26%26%
    26%26%
  • Diarrhea
    25%25%
    27%27%
  • Nausea
    25%25%
    28%28%
  • Joint pain
    25%25%
    18%18%
  • Fever
    23%23%
    35%35%
  • Low red blood cells
    23%23%
    21%21%
  • Acne
    22%22%
    19%19%
  • Low white blood cells
    14%14%
    9%9%
  • Rash
    10%10%
    6%6%
0%
10%
20%
30%
40%
50%
60%
70%
80%
Where we got our data »

The placebo bar shows how common a side effect was for people taking a sugar pill instead of Rapamune.

Rapamune (sirolimus)
Placebo

People taking Rapamune felt side effect more

People taking Rapamune felt side effect less

No difference

Risks and Warnings for Rapamune (sirolimus)

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  • Rapamune (sirolimus) use can cause problems with transplanted lung or liver organs, including early death. People with liver and lung transplants shouldn’t use Rapamune (sirolimus).

    This is a black box warning. The FDA requires this warning when there is a significant risk of serious or life-threatening effects that anyone taking the drug should consider.

Means that some groups have a high risk of experiencing this side effect

Common concerns from people taking Rapamune (sirolimus)

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Interactions
  • Rapamune (sirolimus) can interact with many medicines to cause serious or life-threatening side effects. Talk to your doctor or pharmacist before starting or stopping any medicines.
Kidneys and liver
  • Causes less harm to the kidneys with long-term use than similar medicines.