Sandimmune

(cyclosporine)

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Suppresses the immune system.

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Our bottom line

Sandimmune (cyclosporine) is good at preventing rejection of an organ transplant, but it's more difficult to monitor than Neoral/Gengraf (cyclosporine modified) and isn't good for people with kidney problems.

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    $120.95
Quick facts about Sandimmune
  • Drug class: Transplant
  • Rx status: Prescription only
  • Generic status: Lower-cost generic available (cyclosporine)

Upsides

  • Sandimmune (cyclosporine) is good at preventing organ rejection.
  • Can take Sandimmune (cyclosporine) if you’re pregnant.
  • Less effect on blood sugar than other medicines in its class like tacrolimus.
  • Conveniently taken once daily.
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What to expect from Sandimmune, on one page

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Downsides

  • You’ll need regular blood tests, especially in the beginning, to make sure Sandimmune (cyclosporine) isn't affecting your body in a bad way.
  • Can cause high blood pressure and kidney damage, especially with lifelong use.
  • You might need to take other medicines to control your blood pressure while on Sandimmune (cyclosporine).
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What to expect from Sandimmune, on one page

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How it works

Sandimmune (cyclosporine) is an immunosuppresant that lowers your immune system activity so your body doesn't reject the transplanted organ. It also lowers inflammation in the body.

Quick facts about Sandimmune
  • Drug class: Transplant
  • Rx status: Prescription only
  • Generic status: Lower-cost generic available (cyclosporine)

Used for

  • Prevention of heart transplant rejection
  • Prevention of kidney transplant rejection
  • Prevention of liver transplant rejection

Dosage forms

  • Pill
  • Liquid
Tried Sandimmune? Write a review!

Prices and coupons

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What to expect when you take Sandimmune (cyclosporine) for Prevention of heart transplant rejection

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  • First few hoursHours
    First few daysDays
    First few weeksWeeks
    First few monthsMonths
  • Effectiveness
  • Starts to kick in
    Full effects
  • First few hoursHours
    First few daysDays
    First few weeksWeeks
    First few monthsMonths
  • Possible side effects
  • High blood pressure
  • Tremor
  • Abnormal hair growth
  • Headache
  • Nausea/vomiting
  • Stomach discomfort
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Side effect rates for Sandimmune (cyclosporine)

From 112 clinical trials of Sandimmune when taken for prevention of heart transplant rejection
  • High blood pressure
    53%53%
  • Abnormal kidney function
    38%38%
  • Tremor
    31%31%
  • Abnormal hair growth
    28%28%
  • Headache
    15%15%
  • Nausea/vomiting
    10%10%
  • Liver damage
    7%7%
  • Stomach discomfort
    7%7%
  • Low white blood cells
    6%6%
  • Blood cell tumor
    6%6%
  • Gum swelling
    5%5%
  • Uncontrolled shaking
    4%4%
  • Diarrhea
    4%4%
  • Swelling of breasts
    4%4%
  • Common cold symptoms
    3%3%
  • Acne
    2%2%
  • Burning or tingling in hands, arms, legs, or feet
    2%2%
0%
10%
20%
30%
40%
50%
60%
70%
80%
Where we got our data »

The placebo bar shows how common a side effect was for people taking a sugar pill instead of Sandimmune.

Sandimmune (cyclosporine)
Placebo

People taking Sandimmune felt side effect more

People taking Sandimmune felt side effect less

No difference

Risks and Warnings for Sandimmune (cyclosporine)

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    • Higher risk if:
    • Taking Sandimmune (cyclosporine) for a long time
    • Prolonged exposure to sunlight
    • UV light

    Long-term use of Sandimmune (cyclosporine) can raise your risk of skin cancer and lymphoma (cancer of the immune system). Wear extra protective clothing and sunscreen if you plan on being in the sun, even if it's cloudy. Let your doctor know right away if you have skin changes, prolonged fevers, unexpected weight loss, extreme tiredness, or lumps in your neck, armpit, or groin.

    This is a black box warning. The FDA requires this warning when there is a significant risk of serious or life-threatening effects that anyone taking the drug should consider.

Means that some groups have a high risk of experiencing this side effect

Common concerns from people taking Sandimmune (cyclosporine)

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Interactions
  • Sandimmune (cyclosporine) can interact with many medicines to cause serious or life-threatening side effects. Talk to your doctor or pharmacist before starting or stopping medicines.
Kidneys and liver
  • Sandimmune (cyclosporine) can damage your kidneys, especially if you have poor kidney function or are taking other medicines that can damage the kidneys. Your doctor will order blood tests to check your kidney function and Sandimmune (cyclosporine) levels and will change your dose if needed.
  • Can cause high blood pressure and kidney damage, especially with lifelong use.
Weight
  • Sandimmune (cyclosporine) can raise your risk of serious or life-threatening bacterial, fungal, and viral infections. If you develop symptoms of fever, chills, muscle aches, or you notice dark urine, appetite/weight loss, vomiting, or a skin rash, tell your doctor right away.