Savella

(milnacipran)

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Treats fibromyalgia.

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Our bottom line

While Savella (milnacipran) is one of the only medicines approved to treat fibromyalgia, it can be very expensive, and requires a strict schedule to take it correctly.

Lowest price near you
  • Lowest price with coupon
    $354.90
Quick facts about Savella
  • Drug class: Neuro/psych
  • Rx status: Prescription only
  • Generic status: No lower cost generic available

Upsides

  • Savella (milnacipran) is considered a first choice medicine for treating fibromyalgia.
  • There are programs to make the copay for Savella (milnacipran) more affordable.
  • Savella (milnacipran) can be taken with or without food.
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What to expect from Savella, on one page

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Downsides

  • Savella (milnacipran) is only available as a brand name so it can have a very high copay.
  • You have to take it based on a very strict schedule, which can be confusing during the first month.
  • Taking Savella (milnacipran) by itself usually isn't enough to get relief from fibromyalgia.
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What to expect from Savella, on one page

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How it works

Savella (milnacipran) is a serotonin and norepinephrine reuptake inhibitor. While it's not clear how Savella (milnacipran) treats fibromyalgia, it raises the amount of serotonin and norepinephrine in the brain, which might play a role in pain relief.

Quick facts about Savella
  • Drug class: Neuro/psych
  • Rx status: Prescription only
  • Generic status: No lower cost generic available

Used for

Dosage forms

  • Pill
Tried Savella? Write a review!

Prices and coupons

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What to expect when you take Savella (milnacipran) for Fibromyalgia

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  • First few daysDays
    First few weeksWeeks
    First few monthsMonths
    Long term
  • Effectiveness
  • Starts to kick in
    Full effects
  • First few daysDays
    First few weeksWeeks
    First few monthsMonths
    Long term
  • Possible side effects
  • Higher risk of suicide
  • Changes in blood pressure
  • Changes in heart rate
  • Urination problems in men
  • Bleeding problems
  • Liver damage
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Side effect rates for Savella (milnacipran)

From 2209 clinical trials of Savella when taken for fibromyalgia
  • Nausea
    37%37%
    20%20%
  • Headache
    18%18%
    14%14%
  • Constipation
    16%16%
    4%4%
  • Trouble sleeping
    12%12%
    10%10%
  • Hot flashes
    12%12%
    2%2%
  • Dizziness
    10%10%
    6%6%
  • Excess sweating
    9%9%
    2%2%
  • Palpitations
    7%7%
    2%2%
  • Vomiting
    7%7%
    2%2%
  • Colds or flu
    6%6%
    6%6%
  • Dry mouth
    5%5%
    2%2%
  • Anxiety
    4%4%
    4%4%
  • Abdominal pain
    3%3%
    2%2%
  • High blood pressure
    3%3%
    1%1%
  • Rash
    3%3%
    2%2%
  • Flushing
    3%3%
    1%1%
  • Fast heartbeat
    2%2%
    1%1%
  • Blurry vision
    2%2%
    1%1%
  • Chest pain
    2%2%
    2%2%
  • Chills
    2%2%
  • Loss of appetite
    2%2%
  • Migraine
    2%2%
    2%2%
  • Tingling or prickling sensation
    2%2%
    2%2%
  • Tremor
    2%2%
    1%1%
  • Shortness of breath
    2%2%
    1%1%
0%
10%
20%
30%
40%
50%
60%
70%
80%
Where we got our data »

The placebo bar shows how common a side effect was for people taking a sugar pill instead of Savella.

Savella (milnacipran)
Placebo

People taking Savella felt side effect more

People taking Savella felt side effect less

No difference

Risks and Warnings for Savella (milnacipran)

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    • Higher risk if:
    • People under age 24
    • History of depression or suicide attempts

    Savella (milnacipran) is similar to other drugs in its class based on how it works in the body, and may raise the risk of suicide when starting it. This is more likely if you're under age 24 and if you have depression. If you have depression, or think you might have depression, talk to your doctor first before you start taking Savella (milnacipran), especially if you're already taking medicines to treat it.

    This is a black box warning. The FDA requires this warning when there is a significant risk of serious or life-threatening effects that anyone taking the drug should consider.

Means that some groups have a high risk of experiencing this side effect

Pharmacist Q&A

Savella (milnacipran) questions for

Frequently Asked Questions

This medication treats fibromyalgia.

Who is this drug for?

This medication treats fibromyalgia.

Common concerns from people taking Savella (milnacipran)

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Pregnancy

Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

Tip: Always talk with your doctor before you take any medication while pregnant.
FDA pregnancy category for Savella
CWeigh risks vs. benefits
Food
  • If you're on blood thinners, taking Savella (milnacipran) might make you more likely to bleed. Make sure your doctor knows you're on blood thinners. Your doctor might make changes in how you take those medicines, or your doctor might have you take something else for your fibromyalgia.
  • Savella (milnacipran) can be taken with or without food.