Zoloft

(sertraline)

3.5/ 5 average rating with 1472 reviewsforZoloft
Skip to: drug prices sectionSkip to: what to expect sectionSkip to: side effects sectionSkip to: risks and warnings sectionSkip to: common concerns from users and pharmacists
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Improves mood and helps you relax.

Skip Upsides & Downsides section. Skip to side effects section.

Our bottom line

Zoloft (sertraline) is good for treating depression and anxiety, but it can interact with many medicines.

Lowest price near you
  • Price before coupon
    $12.83
  • Lowest price with coupon
    $8.63
  • Savings
    33%
Quick facts about Zoloft
  • Drug class: Mental health
  • Rx status: Prescription only
  • Generic status: Lower-cost generic available (sertraline)

Upsides

  • One of the more effective and better tolerated antidepressants in its class.
  • Causes less sleepiness than other antidepressants.
  • Available as a generic, which is cheaper.
  • Best choice among antidepressants if you are pregnant.
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What to expect from Zoloft, on one page

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People’s experience with Zoloft

1472reviews so far. What do you think?

Downsides

  • Takes at least 1 to 2 weeks to kick in and can take up to 12 weeks for maximum effect.
  • Can cause low sex drive, an inability to orgasm or ejaculate, and minor weight gain (1 to 5 pounds).
  • Is more likely to cause diarrhea compared to other antidepressants.
  • Interacts with lots of other medicines.
  • You may need to try out several different antidepressants before you find the one that works for you.
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What to expect from Zoloft, on one page

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How it works

Zoloft (sertraline) is a selective serotonin reuptake inhibitor (SSRI) antidepressant. It raises serotonin levels in the brain, which affects mood.

Quick facts about Zoloft
  • Drug class: Mental health
  • Rx status: Prescription only
  • Generic status: Lower-cost generic available (sertraline)

Used for

Dosage forms

  • Pill
  • Liquid
People’s experience with Zoloft

1472reviews so far. What do you think?

Prices and coupons

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What to expect when you take Zoloft (sertraline) for Premenstrual dysphoric disorder (luteal phase dosing)

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  • First few hoursHours
    First few daysDays
    First few weeksWeeks
    First few monthsMonths
  • Effectiveness
  • Starts to kick in
    Full effects
  • First few hoursHours
    First few daysDays
    First few weeksWeeks
    First few monthsMonths
  • Possible side effects
  • Fatigue
  • Nausea
  • Dry mouth
  • Diarrhea
  • Loss of appetite
  • Upset stomach
Skip side effects section. Skip to risks and warnings section.

Side effect rates for Zoloft (sertraline)

From 1714 clinical trials of Zoloft when taken for depression (50 to 200 mg/day)
  • Nausea
    26%26%
    12%12%
  • Diarrhea
    18%18%
    9%9%
  • Dry mouth
    16%16%
    9%9%
  • Difficulty sleeping
    16%16%
    9%9%
  • Drowsiness
    13%13%
    6%6%
  • Dizziness
    12%12%
    7%7%
  • Tremor
    11%11%
    3%3%
  • Fatigue
    11%11%
    8%8%
  • More sweating
    8%8%
    3%3%
  • Constipation
    8%8%
    6%6%
  • Ejaculation failure
    7%7%
  • Upset stomach
    6%6%
    3%3%
  • Agitation
    6%6%
    4%4%
  • Loss of appetite
    3%3%
    2%2%
  • Stomach pain
    2%2%
    2%2%
0%
10%
20%
30%
40%
50%
60%
70%
80%
Where we got our data »

The placebo bar shows how common a side effect was for people taking a sugar pill instead of Zoloft.

Zoloft (sertraline)
Placebo

People taking Zoloft felt side effect more

People taking Zoloft felt side effect less

No difference

Risks and Warnings for Zoloft (sertraline)

Skip risks section. Skip to common concerns section.
    • Higher risk if:
    • Age 24 years or younger

    Zoloft (sertraline) may raise the risk of suicidal thoughts or behavior. Watch out for worsening depression or any unusual changes in mood or behavior, especially during the first few months of treatment or when the dose changes. Tell your doctor right away if you experience any of these thoughts.

    This is a black box warning. The FDA requires this warning when there is a significant risk of serious or life-threatening effects that anyone taking the drug should consider.

Means that some groups have a high risk of experiencing this side effect

Pharmacist Q&A

Zoloft (sertraline) questions for

Frequently Asked Questions

This medication treats depression.

Who is this drug for?

This medication treats depression.

Common concerns from people taking Zoloft (sertraline)

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Interactions
  • Interacts with lots of other medicines.
  • Worth it
    Some hassle
    Reviewed Zolofton 9/10/2016May be helpful to take something to counteract the diarrhea and nausea
    20
    Woman
    Depression
Alcohol
  • Worth it
    Some hassle
    Reviewed sertralineon 2/23/2018Don't binge drink alcohol! Take it easy.
    22
    Man
    A few months
    Would rather not say
  • Worth it
    Some hassle
    Reviewed Zolofton 3/26/2017Be careful with alcohol. You get drunker much quicker, and don't remember much.
    35
    Man
    Two years or more
    Anxiety
Food
  • Worth it
    Low hassle
    Reviewed Zolofton 10/5/2017Take it in the morning and you will have no desire to eat food. Weight falls off of you. Found comfort in being outside, and watching the world instead of worrying about my problems.
    16
    Woman
    A few months
    Depression
  • Worth it
    Some hassle
    Reviewed Zolofton 8/14/2017Take it with food at first
    24
    Woman
    A few months
    Anxiety
  • Worth it
    Some hassle
    Reviewed Zolofton 7/10/2017Take with food; otherwise, your stomach will have horrible pain and sick feeling overall. Not all generics work as well as others. Take with consistency. Getting off it is very hard. I've been on it for 21 years. Going off it causes dizziness and sick feeling. Staying on it causes sleepiness and energy zapping, or I'm just getting old.
    43
    Man
    Two years or more
    Anxiety
Pain
  • Not worth it
    Big hassle
    Reviewed Zolofton 5/26/2017I got good effect after 7 weeks but joint pain moved in. Intolerable by week 12. Moved on to Prozac.
    60
    Man
    A few months
    PTSD
  • Worth it
    Some hassle
    Reviewed Zolofton 7/14/2016Caused stomach pain when taken before bed..none when I take with food in the morning
    58
    Man
    Panic disorder
Sex
  • Worth it
    Some hassle
    Reviewed Zolofton 3/3/2017Stick with it. Libido returned after 4 weeks, bowels still unstable. Take propanolol if anxiety comes on. Spasm pains rare now. Not taking ibuprofen or paracetamol these days. Sleep is bad. That's the worst. 4 to 6 hours of poor sleep.
    60
    Man
    A few months
    Anxiety
  • Not sure
    Big hassle
    Reviewed ZoloftComplete loss of libido. Became an asexual zombie, lost all emotion, apathetic, numb, ruined relationships and became type A workaholic. But, on the bright side, I ended up becoming a strait A student.
    18
    Woman
    A year or so
    Anxiety
  • Not worth it
    Big hassle
    Reviewed ZoloftI gained 25 pounds and it wiped out my libido- felt fat and flat and nearly destroyed my marriage due to the lack of sexual interest. Made me have uncontrollable sweating.
    36
    Woman
    A year or so
    PTSD
Sleep
  • Worth it
    Some hassle
    Reviewed Zolofton 8/27/2016Feeling very tired for weeks after an increase, is normal. Also, try taking it at night, to help manage tiredness. Also- drink a lot of water, and bring it with you. You will sweat more. Try swimming, to keep cool. Use w/counseling.
    34
    Woman
    Depression
  • Worth it
    Some hassle
    Reviewed sertralineon 2/25/2018I take it at night to avoid day drowsiness.
    28
    Woman
    A few months
    Anxiety
  • Not sure
    Some hassle
    Reviewed sertralineon 10/6/2017Take with food or take an hour before your alarm and go back to sleep
    21
    Man
    A few months
    Anxiety
Weight
  • Worth it
    Some hassle
    Reviewed sertralineon 10/7/2017Is really good but pays not to miss more than a couple of days as i have experienced a side effect of real dizziness and sore tummy also i have gain heaps of weight while on it but not certain it because of this drug. Has been great for anxiety depression and my pms and ocd
    29
    Woman
    Anxiety
  • Not worth it
    Big hassle
    Reviewed Zolofton 8/22/2017The significant weight gain and digestive system issues (loose stool, nausea) I experienced on sertraline outweighed the benefits I received in terms of managing my depression.
    55
    Man
    A few months
    Depression
  • Worth it
    Some hassle
    Reviewed Zolofton 7/17/2017It briefly increased anxiety at first. My doctor prescribed me a relaxing medication to take until the anti-anxiety effects outweighed the increased anxiety, which took about 10 days.
    41
    Woman
    A few months
    Anxiety

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