Serzone

(nefazodone)

Skip to: drug prices sectionSkip to: what to expect sectionSkip to: side effects sectionSkip to: risks and warnings sectionSkip to: common concerns from users and pharmacists
ADVERTISEMENT

Treats depression.

Skip Upsides & Downsides section. Skip to side effects section.

Our bottom line

Serzone (nefazodone) is usually used with other medicines to treat depression, but it is more likely to cause liver damage.

Lowest price near you
  • Lowest price with coupon
    $78.02
Quick facts about nefazodone
  • Drug class: Neuro/psych
  • Rx status: Prescription only
  • Generic status: Lower-cost generic available (nefazodone)

Upsides

  • Serzone (nefazodone) is a good choice to take with other medicines for depression if they haven't worked by themselves.
  • Serzone (nefazodone) is available in generic.
Get the newsletter!

Sign up and get Pill Talk, the latest in health & medicine news from Iodine

Get our free fact sheet

What to expect from nefazodone, on one page

Download Fact Sheet
Tried nefazodone? Write a review!

Downsides

  • While Serzone (nefazodone) is available as a generic, it's not considered a first or second choice medicine for depression because it is more likely to cause liver damage than other similar medicines.
  • Serzone (nefazodone) is usually taken 2 times a day; the first choice medicines are only taken 1 time a day.
  • It can take up to 3 months before you notice the full effects of Serzone (nefazodone).
  • Compared to other similar medicines, Serzone (nefazodone) has a lot of interactions with other drugs, so your doctor might have to adjust the doses of your other medicines.
Get the newsletter!

Sign up and get Pill Talk, the latest in health & medicine news from Iodine

Get our free fact sheet

What to expect from nefazodone, on one page

Download Fact Sheet
How it works

Serzone (nefazodone) is a serotonin reuptake inhibitor. Serzone (nefazodone) raises the amount of serotonin in the brain, which helps to regulate your mood.

Quick facts about nefazodone
  • Drug class: Neuro/psych
  • Rx status: Prescription only
  • Generic status: Lower-cost generic available (nefazodone)

Used for

Dosage forms

  • Pill
Tried nefazodone? Write a review!

Prices and coupons

Skip prices section. Skip to what to expect section.
Prices and coupons for 60 (200mg) tablets of nefazodone near
Sign up now for a 30-day trial and save up to 95% at CVS, Kroger, Albertsons, and other pharmacies.
Learn more
See more prices and coupons in your area

What to expect when you take Serzone (nefazodone) for Depression

Skip what to expect section. Skip to side effects section.
  • First few hoursHours
    First few daysDays
    First few weeksWeeks
    First few monthsMonths
  • Effectiveness
  • Starts to kick in
    Full effects
  • First few hoursHours
    First few daysDays
    First few weeksWeeks
    First few monthsMonths
  • Possible side effects
  • Low blood pressure
  • Slowed heartbeat
  • Liver damage
  • Seizures
  • Bipolar disorder
Skip side effects section. Skip to risks and warnings section.

Side effect rates for Serzone (nefazodone)

From 787 clinical trials of nefazodone when taken for depression (300-600mg/day)
  • Headache
    36%36%
    33%33%
  • Dry mouth
    25%25%
    13%13%
  • Sleepiness
    25%25%
    14%14%
  • Nausea
    22%22%
    12%12%
  • Dizziness
    17%17%
    5%5%
  • Constipation
    14%14%
    8%8%
  • Weakness
    11%11%
    5%5%
  • Trouble sleeping
    11%11%
    9%9%
  • Lightheadedness
    10%10%
    3%3%
  • Indigestion
    9%9%
    7%7%
  • Blurry vision
    9%9%
    3%3%
  • Infection
    8%8%
    6%6%
  • Diarrhea
    8%8%
    7%7%
  • Confusion
    7%7%
    2%2%
  • Blind spots in vision
    7%7%
    1%1%
  • Sore throat
    6%6%
    5%5%
  • Increased appetite
    5%5%
    3%3%
  • Changes in blood pressure
    4%4%
    1%1%
  • Memory problems
    4%4%
    2%2%
  • Tingling or prickling sensation
    4%4%
    2%2%
  • Flushing
    4%4%
    2%2%
  • Flu
    3%3%
    2%2%
  • Swelling in the arms and legs
    3%3%
    2%2%
  • Abnormal dreams
    3%3%
    2%2%
  • Decreased concentration
    3%3%
    1%1%
  • Increased cough
    3%3%
    1%1%
  • Chills
    2%2%
    1%1%
  • Fever
    2%2%
    1%1%
  • Low blood pressure
    2%2%
    1%1%
  • Itching
    2%2%
    1%1%
  • Skin rashes
    2%2%
    1%1%
  • Nausea and vomiting
    2%2%
    1%1%
  • Trouble controlling movements
    2%2%
  • Coordination problems
    2%2%
    1%1%
  • Slowing of movement or speech
    2%2%
    1%1%
  • Tremor
    2%2%
    1%1%
  • Ringing in the ears
    2%2%
    1%1%
  • Changes in taste
    2%2%
    1%1%
  • Frequent urination
    2%2%
    1%1%
  • Urinary tract infection
    2%2%
    1%1%
  • Problems emptying bladder
    2%2%
    1%1%
  • Vaginal discharge, itching, and pain
    2%2%
    1%1%
0%
10%
20%
30%
40%
50%
60%
70%
80%
Where we got our data »

The placebo bar shows how common a side effect was for people taking a sugar pill instead of nefazodone.

Serzone (nefazodone)
Placebo

People taking nefazodone felt side effect more

People taking nefazodone felt side effect less

No difference

Risks and Warnings for Serzone (nefazodone)

Skip risks section. Skip to common concerns section.
    • Higher risk if:
    • People under age 24

    People who take medicines similar to Serzone (nefazodone) are at higher risk for suicide. This is more likely to happen in people under age 24. Talk to your doctor right away if you feel your mood begins to darken or you want to hurt yourself or other people.

    This is a black box warning. The FDA requires this warning when there is a significant risk of serious or life-threatening effects that anyone taking the drug should consider.

Means that some groups have a high risk of experiencing this side effect

Pharmacist Q&A

Serzone (nefazodone) questions for

Frequently Asked Questions

This medication treats depression.

Who is this drug for?

This medication treats depression.

Common concerns from people taking Serzone (nefazodone)

Final section. Do you want to return to drug navigation?
Pregnancy

Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

Tip: Always talk with your doctor before you take any medication while pregnant.
FDA pregnancy category for nefazodone
CWeigh risks vs. benefits
Interactions
  • Compared to other similar medicines, Serzone (nefazodone) has a lot of interactions with other drugs, so your doctor might have to adjust the doses of your other medicines.
Pain
  • Talk to your doctor right away if you notice yellowing in the whites of your eyes or your skin, a high fever, pain in your stomach, or dark urine.