Silenor

(Doxepin)

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Helps you relax, and sleep.

Skip Upsides & Downsides section. Skip to side effects section.

Our bottom line

Doxepin is a non-addictive way to help people stay asleep, but it comes with a list of side effects.

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Quick facts about Silenor
  • Drug class: Neuro/psych
  • Generic status: Lower-cost generic available (doxepin)

Upsides

  • In a clinical trial Doxepin was able to significantly improve sleep quality.
  • Doxepin helps improve your appetite, energy level, and sense of well-being, which increases your interests.
  • Once your body gets used to Doxepin, most of the side effects go away.
  • Doxepin comes in a generic form, so it is pretty cheap.
  • Doxepin is not addictive.
Tried Silenor? Write a review!

Downsides

  • Some people taking Doxepin walk, drive, eat, and have sex while sleeping. Be sure to tell your doctor if this happens to you.
  • Doxepin can increase your appetite, leading to weight gain.
  • Taking Doxepin can make emptying your bladder difficult.
  • Some people have suicidal thoughts when taking Doxepin.
  • Doxepin can interact with many different medications, vitamins, and alternative treatments.
How it works

Doxepin is a tricyclic antidepressant. It keeps norepinephrine and serotonin in your brain longer, helping you relax, and sleep. It also blocks the chemical that causes itch, and wakefulness.

Quick facts about Silenor
  • Drug class: Neuro/psych
  • Generic status: Lower-cost generic available (doxepin)

Used for

  • Alcoholism - Anxiety - Depression Anxiety - Depression Anxiety - Depression - Psychoneurotic personality disorder Insomnia Pruritus (Moderate)
  • Due to atopic dermatitis or lichen simplex chronicus
  • Urticaria

Dosage forms

  • Pill
  • Liquid
Tried Silenor? Write a review!

Prices and coupons

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Side effect rates for Silenor (Doxepin)

0 reports
These are side effects of Silenor (Doxepin) reported to the FDA by people taking it, and by doctors and pharmacists.
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Common concerns from people taking Silenor (Doxepin)

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Pregnancy

Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

See the FDA package insertSee pregnancy safe medications
Tip: Always talk with your doctor before you take any medication while pregnant.
FDA pregnancy category for Silenor
CWeigh risks vs. benefits
Interactions
  • Doxepin can interact with many different medications, vitamins, and alternative treatments.
Alcohol
  • Stay away from alcohol while taking Doxepin, because it can slow your brain, and stop your breathing.
Sleep
  • Worth it
    Worked well
    Low hassle
    Reviewed Silenoron 3/2/2017Go lie down to sleep no longer than 15 mins after taking doxepin and try not to drink a lot of liquids close to bedtime (I find I only experience dry mouth/throat if I do not go to bed immediately and if I stay up after it hits,I feel manic and energetic but will fall asleep sitting up with no notice).Do not drink a lot of fluids before bedtime until you know how it affects you ( possible trouble urinating).
    38
    Woman
    A year or so
    Alcoholism - Anxiety - Depression Anxiety - Depression Anxiety - Depression - Psychoneurotic personality disorder Insomnia Pruritus (Moderate)
Weight
  • Doxepin can increase your appetite, leading to weight gain.