Simponi

(golimumab)

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Calms down the immune system.

Skip Upsides & Downsides section. Skip to side effects section.

Our bottom line

Simponi (golimumab) effectively calms down your immune system, but it is given as a shot and puts you at risk of serious infections like tuberculosis or hepatitis B.

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Quick facts about Simponi
  • Drug class: Autoimmune
  • Rx status: Prescription only
  • Generic status: No lower cost generic available

Upsides

  • Simponi (golimumab) is only injected once a month.
  • Simponi (golimumab) comes in a prefilled syringe or autoinjector. You won't need to measure out the medication.
  • While taking Simponi (golimumab), you may continue to use other drugs prescribed by your doctor that help treat your condition, such as NSAIDS (like ibuprofen) and steroids.
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What to expect from Simponi, on one page

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Downsides

  • Like other immunosuppressive drugs, Simponi (golimumab) can awaken (reactivate) infections.
  • Simponi (golimumab) can increase the risk of lymphoma, leukemia, and other cancers.
  • Not the best choice if you have a history of heart failure or nervous system problems like multiple sclerosis.
  • You'll need to have regular blood tests before and during treatment to make sure you don't have any problems taking Simponi (golimumab).
Get our free fact sheet

What to expect from Simponi, on one page

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How it works

Simponi (golimumab) blocks a protein called TNF (tumor necrosis factor) that revs up the immune system. Blocking TNF lowers inflammation, relieves symptoms and prevents disease progression. Simponi (golimumab) is also known as a biologic DMARD (disease-modifying anti-rheumatic drug) - or just a "biologic" - when used to treat rheumatoid arthritis.

Quick facts about Simponi
  • Drug class: Autoimmune
  • Rx status: Prescription only
  • Generic status: No lower cost generic available

Used for

Dosage forms

  • Injection
Tried Simponi? Write a review!

Prices and coupons

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What to expect when you take Simponi (golimumab) for Rheumatoid arthritis, psoriatic arthritis, and ankylosing spondylitis

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  • First few hoursHours
    First few daysDays
    First few weeksWeeks
    First few monthsMonths
  • Effectiveness
  • Starts to kick in
    Full effects
  • First few hoursHours
    First few daysDays
    First few weeksWeeks
    First few monthsMonths
  • Possible side effects
  • Common cold
  • Injection site reactions
  • Viral infections (such as influenza and herpes)
  • Bronchitis
  • Superficial fungal infections
  • Sinusitis
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Side effect rates for Simponi (golimumab)

From 2298 clinical trials of Simponi when taken for null
  • Common cold
    16%16%
    13%13%
  • Injection site reaction
    6%6%
    2%2%
  • Viral infections (such as influenza and herpes)
    5%5%
    3%3%
  • Increased liver function test (ALT)
    4%4%
    3%3%
  • Increased liver function test (AST)
    3%3%
    2%2%
  • High blood pressure
    3%3%
    2%2%
  • Bronchitis
    2%2%
    1%1%
  • Superficial fungal infections
    2%2%
    1%1%
  • Sinusitis
    2%2%
    1%1%
  • Dizziness
    2%2%
    1%1%
  • Tingling sensation
    2%2%
    1%1%
0%
10%
20%
30%
40%
50%
60%
70%
80%
Where we got our data »

The placebo bar shows how common a side effect was for people taking a sugar pill instead of Simponi.

Simponi (golimumab)
Placebo

People taking Simponi felt side effect more

People taking Simponi felt side effect less

No difference

Risks and Warnings for Simponi (golimumab)

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    • Higher risk if:
    • › Taking other immunosuppressant drugs
    • › Age 65 or older
    • › Active, chronic, or recurrent infection

    Simponi (golimumab) can increase your risk of serious or life-threatening infections. In some cases, existing inactive infections can be reactivated such as tuberculosis (TB) or hepatitis B virus (HBV). You may need to take medicine for TB before you can begin taking Simponi (golimumab). If you develop symptoms of cough, fever, chills, muscle aches, fatigue, dark urine, yellowing of skin/eyes, appetite/weight loss, vomiting, change in stool color, stomach discomfort, or skin rash, tell your doctor and get medical care right away.

    This is a black box warning. The FDA requires this warning when there is a significant risk of serious or life-threatening effects that anyone taking the drug should consider.

Means that some groups have a high risk of experiencing this side effect

Common concerns from people taking Simponi (golimumab)

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Price
  • Not sure
    Didn’t work
    Some hassle
    Reviewed Simponi Ariaon 8/13/2021Would take remicade next,all medicine is priced so high,I hope big pharma can help all,I really do.
    59
    Man
    A few months
    Rheumatoid arthritis