Sovaldi

(sofosbuvir)

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Treats hepatitis C infection.

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Our bottom line

Sovaldi (sofosbuvir) is an effective medicine to treat chronic hepatitis C infection, but it must be used with other antiviral medicines.

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    $27812.55
Quick facts about Sovaldi
  • Drug class: Infection
  • Rx status: Prescription only
  • Generic status: No lower cost generic available

Upsides

  • Most people who use Sovaldi (sofosbuvir) have good results, and often find no traces of the hepatitis C infection in their blood three months later.
  • This treatment works well for people who have hepatitis C and HIV, liver cancer, or who are waiting for a liver transplant.
  • Sovaldi (sofosbuvir) is only taken once a day.
  • Sovaldi (sofosbuvir) has fewer side effects than other medications used to treat this infection.
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What to expect from Sovaldi, on one page

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Downsides

  • There's no generic available, so it can be very expensive.
  • Must be used with other antiviral medicines, such as ribavirin and/or peginterferon alfa.
  • Sovaldi (sofosbuvir) doesn't treat all 6 types of hepatitis C.
  • This medicine isn't the best choice if you have kidney problems.
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What to expect from Sovaldi, on one page

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How it works

Sovaldi (sofosbuvir) is an antiviral medicine. It stops the hepatitis C virus (HCV) from multiplying in your body.

Quick facts about Sovaldi
  • Drug class: Infection
  • Rx status: Prescription only
  • Generic status: No lower cost generic available

Used for

Dosage forms

  • Pill
Tried Sovaldi? Write a review!

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What to expect when you take Sovaldi (sofosbuvir) for Hepatitis C

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  • First few hoursHours
    First few daysDays
    First few weeksWeeks
    First few monthsMonths
  • Effectiveness
  • Starts to kick in
    Full effects
  • First few hoursHours
    First few daysDays
    First few weeksWeeks
    First few monthsMonths
  • Possible side effects
  • Fatigue
  • Headache
  • Nausea
  • Difficulty sleeping
  • Itchy skin
  • Weakness
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Side effect rates for Sovaldi (sofosbuvir)

From 721 clinical trials of Sovaldi when taken for hepatitis c
  • Fatigue
    59%59%
    24%24%
  • Headache
    44%44%
    20%20%
  • Fatigue
    38%38%
    24%24%
  • Headache
    36%36%
    20%20%
  • Nausea
    34%34%
    18%18%
  • Fatigue
    30%30%
    24%24%
  • Headache
    30%30%
    20%20%
  • Nausea
    28%28%
    18%18%
  • Difficulty sleeping
    28%28%
    4%4%
  • Itchy skin
    27%27%
    8%8%
  • Difficulty sleeping
    25%25%
    4%4%
  • Headache
    24%24%
    20%20%
  • Nausea
    22%22%
    18%18%
  • Weakness
    21%21%
    3%3%
  • Low red blood cells
    21%21%
  • Rash
    18%18%
    8%8%
  • Lower appetite
    18%18%
    10%10%
  • Chills
    18%18%
    1%1%
  • Flu-like symptoms
    18%18%
    3%3%
  • Rash
    18%18%
    8%8%
  • Lower appetite
    18%18%
    10%10%
  • Fever
    18%18%
  • Itchy skin
    17%17%
    8%8%
  • Diarrhea
    17%17%
    6%6%
  • Itchy skin
    17%17%
    8%8%
  • Chills
    17%17%
    1%1%
  • Low neutrophils (type of white blood cells)
    17%17%
  • Difficulty sleeping
    16%16%
    4%4%
  • Muscle pain
    16%16%
  • Irritability
    16%16%
    1%1%
  • Flu-like symptoms
    16%16%
    3%3%
  • Difficulty sleeping
    15%15%
    4%4%
  • Fever
    14%14%
  • Muscle pain
    14%14%
  • Nausea
    13%13%
    18%18%
  • Irritability
    13%13%
    1%1%
  • Diarrhea
    12%12%
    6%6%
  • Low red blood cells
    12%12%
  • Low neutrophils (type of white blood cells)
    12%12%
  • Diarrhea
    12%12%
    6%6%
  • Itchy skin
    11%11%
    8%8%
  • Low red blood cells
    10%10%
  • Irritability
    10%10%
    1%1%
  • Diarrhea
    9%9%
    6%6%
  • Rash
    9%9%
    8%8%
  • Muscle pain
    9%9%
  • Rash
    8%8%
    8%8%
  • Weakness
    6%6%
    3%3%
  • Lower appetite
    6%6%
    10%10%
  • Muscle pain
    6%6%
  • Low red blood cells
    6%6%
  • Lower appetite
    6%6%
    10%10%
  • Flu-like symptoms
    6%6%
    3%3%
  • Weakness
    5%5%
    3%3%
  • Fever
    4%4%
  • Flu-like symptoms
    3%3%
    3%3%
  • Weakness
    3%3%
    3%3%
  • Chills
    2%2%
    1%1%
0%
10%
20%
30%
40%
50%
60%
70%
80%
Where we got our data »

The placebo bar shows how common a side effect was for people taking a sugar pill instead of Sovaldi.

Sovaldi (sofosbuvir)
Placebo

People taking Sovaldi felt side effect more

People taking Sovaldi felt side effect less

No difference

Risks and Warnings for Sovaldi (sofosbuvir)

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    • Higher risk if:
    • History of or active hepatitis B infection

    If you've had hepatitis B in the past, or currently have it, Sovaldi (sofosbuvir) can make it come back or get worse. Before you start using Sovaldi (sofosbuvir), you'll need to be tested for hepatitis B. Tell your doctor if you've ever had hepatitis B or have been treated for it in the past.

    This is a black box warning. The FDA requires this warning when there is a significant risk of serious or life-threatening effects that anyone taking the drug should consider.

Means that some groups have a high risk of experiencing this side effect

Common concerns from people taking Sovaldi (sofosbuvir)

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Interactions
  • Sovaldi (sofosbuvir) can interact with many medicines and cause serious or life-threatening side effects. Talk to your doctor or pharmacist about your current medicines and make sure they know if you'll be starting or stopping any new prescription medicines, vitamins, or supplements.
  • There are many interactions between Sovaldi (sofosbuvir) and other medicines and herbal supplements, so talk to your doctor or pharmacist before starting anything new.
Kidneys and liver
  • Depending on your type of hepatitis C infection, you'll take Sovaldi (sofosbuvir) for either 12 weeks or 24 weeks. Don't stop using it early or make any other changes without first talking to your doctor or pharmacist.
  • Sovaldi (sofosbuvir) doesn't treat all 6 types of hepatitis C.
  • This medicine isn't the best choice if you have kidney problems.