Sustol

(granisetron)

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Helps prevent nausea and vomiting due to cancer chemotherapies.

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Sustol (granisetron) is a long-acting injection that helps to prevent nausea and vomiting due to cancer chemotherapies, but causes bleeding and bruising at the injection site.

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    $123.13
Quick facts about Sustol
  • Drug class: gastrointestinal
  • Rx status:
  • Generic status: No lower cost generic available

Upsides

  • Each dose of Sustol (granisetron) provides relief from nausea and vomiting for at least 7 days.
  • Dosing is less frequent than alternatives.
  • Injection may be preferrable if you have difficulty swallowing a pill.
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Downsides

  • Sustol (granisetron) must be given at the doctor's office or infusion center 30 minutes before chemotherapy.
  • The dose of Sustol (granisetron) needs to be adjusted if you have poor kidney function.
  • Available as an expensive, branded product only.
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How it works

Sustol (granisetron) is 5-HT3 receptor antagonist. It blocks a specific type of serotonin receptor, which is responsible for activating the vomiting response.

Quick facts about Sustol
  • Drug class: gastrointestinal
  • Rx status:
  • Generic status: No lower cost generic available

Used for

  • Prevention of nausea and vomiting due to cancer chemotherapy

Dosage forms

  • Extended-release injection
Tried Sustol? Write a review!

Prices and coupons

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What to expect when you take Sustol (granisetron) for Prevention of nausea and vomiting due to cancer chemotherapies

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  • First few hoursHours
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  • Effectiveness
  • Starts to kick in
    Full effects
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  • Possible side effects
  • Injection site reactions
  • Constipation
  • Fatigue
  • Headache
  • Diarrhea
  • Abdominal pain
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Side effect rates for Sustol (granisetron)

Risks and Warnings for Sustol (granisetron)

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    • Higher risk if:
    • Taking other medicines that affect serotonin levels such as anti-depressants

    Serotonin syndrome is a rare, but serious problem caused by high levels of serotonin in the brain. This may occur if you also take other medicines that affect your serotonin levels such as anti-depressants. Call your doctor or go to the hospital right away if you experience agitation, confusion, hallucinations, high fever, or muscle twitching while taking Sustol (granisetron).

Common concerns from people taking Sustol (granisetron)

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Kidneys and liver
  • The dose of Sustol (granisetron) needs to be adjusted if you have poor kidney function.
Pain
  • Bruising, pain, and tenderness may occur at injection site for up to 2 weeks after use. Contact your doctor if injection site reactions last more than one day or become severe.