Symbyax

(olanzapine / fluoxetine)

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Treats depression and bipolar disorder.

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Our bottom line

Symbyax (olanzapine / fluoxetine) is recommended for people who have bipolar disorder with depression, but you're likely to have issues with weight gain and blood sugar.

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    $97.85
Quick facts about Symbyax
  • Drug class: Neuro/psych
  • Rx status: Prescription only
  • Generic status: Lower-cost generic available (olanzapine / fluoxetine)

Upsides

  • The combination of medicines in Symbyax (olanzapine / fluoxetine) is recommended for people age 10 and older who have bipolar disorder with depression, since it stops people from having manic episodes.
  • Symbyax (olanzapine / fluoxetine) can help people with depression who haven’t had enough improvement with other medications.
  • Symbyax (olanzapine / fluoxetine) reduces the number of pills you have to take per day.
  • Available in generic form, so it can be less costly.
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What to expect from Symbyax, on one page

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Downsides

  • Symbyax (olanzapine / fluoxetine) is available only in certain fixed strengths, so it can be hard to customize dosing.
  • It may take 4 to 6 weeks to experience the full benefits of the medication.
  • Your doctor might have to change the dose of Symbyax (olanzapine / fluoxetine) several times before he/she finds a dose that works best for you.
  • Stopping Symbyax (olanzapine / fluoxetine) suddenly can make your depression or bipolar disorder worse.
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What to expect from Symbyax, on one page

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How it works

Symbyax (olanzapine / fluoxetine) contains 2 medicines: fluoxetine and olanzapine. It raises chemicals in your brain that regulate your mood.

Quick facts about Symbyax
  • Drug class: Neuro/psych
  • Rx status: Prescription only
  • Generic status: Lower-cost generic available (olanzapine / fluoxetine)

Dosage forms

  • Pill
Tried Symbyax? Write a review!

Prices and coupons

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What to expect when you take Symbyax (olanzapine / fluoxetine) for Bipolar disorder or depression

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  • First few hoursHours
    First few daysDays
    First few weeksWeeks
    First few monthsMonths
  • Effectiveness
  • Starts to kick in
    Full effects
  • First few hoursHours
    First few daysDays
    First few weeksWeeks
    First few monthsMonths
  • Possible side effects
  • Dry mouth
  • Swelling
  • Skin allergies and rashes
  • Difficulty controlling movements
  • Changes in blood pressure
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Side effect rates for Symbyax (olanzapine / fluoxetine)

From 255 clinical trials of Symbyax when taken for bipolar depression
  • Sleepiness
    24%24%
    2%2%
  • Weight gain
    20%20%
    1%1%
  • Increased appetite
    17%17%
    1%1%
  • Tremor
    9%9%
    1%1%
  • Higher liver enzymes
    9%9%
    1%1%
  • Higher fat in the blood
    7%7%
    2%2%
  • High cholesterol
    4%4%
  • Upset stomach
    3%3%
    1%1%
  • Anxiety
    3%3%
    1%1%
  • Restlessness
    3%3%
    1%1%
  • Accidental overdose
    3%3%
    1%1%
  • Thoughts of suicide
    2%2%
    1%1%
  • Back pain
    2%2%
    1%1%
  • Menstrual cramps
    2%2%
0%
10%
20%
30%
40%
50%
60%
70%
80%
Where we got our data »

The placebo bar shows how common a side effect was for people taking a sugar pill instead of Symbyax.

Symbyax (olanzapine / fluoxetine)
Placebo

People taking Symbyax felt side effect more

People taking Symbyax felt side effect less

No difference

Risks and Warnings for Symbyax (olanzapine / fluoxetine)

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    • Higher risk if:
    • People age 24 and younger

    Taking Symbyax (olanzapine / fluoxetine) can make you more likely to harm yourself or commit suicide, especially if you are age 24 and younger, and during the first few weeks of taking it. Symbyax (olanzapine / fluoxetine) isn’t approved for children under age 10. If your mood darkens and you want to hurt yourself or other people, call the doctor right away.

    This is a black box warning. The FDA requires this warning when there is a significant risk of serious or life-threatening effects that anyone taking the drug should consider.

Means that some groups have a high risk of experiencing this side effect

Pharmacist Q&A

Symbyax (olanzapine / fluoxetine) questions for

Frequently Asked Questions

This medication is prescribed to treat depressive episodes in adults with bipolar disorder.

Who is this drug for?

This medication is prescribed to treat depressive episodes in adults with bipolar disorder.

Common concerns from people taking Symbyax (olanzapine / fluoxetine)

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Weight
  • Symbyax (olanzapine / fluoxetine) can cause higher weight, blood sugar, cholesterol, and triglycerides (fat), especially in children ages 10 to 17. If you or your child has diabetes, high blood pressure, or heart disease, your doctor might change your medicines and do regular blood tests. Eat healthy and exercise regularly. If you experience excessive thirst, hunger, urination, or weakness, check your blood sugar right away. Report any changes you notice to your doctor.