Treximet

(sumatriptan / naproxen)

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Treats migraine headaches.

Skip Upsides & Downsides section. Skip to side effects section.

Our bottom line

Treximet (sumatriptan / naproxen) treats migraines as they're happening, but you might need another medication to prevent migraine headaches if you get them regularly.

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    $259.01
Quick facts about Treximet
  • Drug class: neurology
  • Rx status: Prescription only
  • Generic status: No lower cost generic available

Upsides

  • Treximet (sumatriptan / naproxen) is a combination of two medications in one pill.
  • Many people who take this drug experience relief and do not need to take an additional "rescue" medicine after taking Treximet (sumatriptan / naproxen).
  • Can take with or without food.
  • May start to work faster than triptan medications alone.
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What to expect from Treximet, on one page

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Downsides

  • Treximet (sumatriptan / naproxen) is not used to prevent or lower the number of migraine headaches you have. You take it when a migraine is already happening.
  • If you feel little relief, you must wait 2 hours after taking one dose before taking a second dose.
  • Treximet (sumatriptan / naproxen) is not used for cluster headaches (which cause great pain around your eyes).
  • Can cause heart problems. You should have your blood pressure checked often when taking this medication.
  • Can also cause stomach problems. Let your doctor know if you've ever had ulcers or bleeding in your stomach.
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What to expect from Treximet, on one page

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How it works

Treximet (sumatriptan / naproxen) is a combination medication that treats migraine headaches. Sumatriptan relieves migraines by constricting certain blood vessels in your head. Naproxen decreases general inflammation and pain related to migraine headaches.

Quick facts about Treximet
  • Drug class: neurology
  • Rx status: Prescription only
  • Generic status: No lower cost generic available

Used for

Dosage forms

  • Pill
Tried Treximet? Write a review!

Prices and coupons

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What to expect when you take Treximet (sumatriptan / naproxen) for Migraines

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  • Effectiveness
  • Full effects
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  • Possible side effects
  • Dizziness
  • Sleepiness
  • Nausea
  • Jaw / neck pressure
  • Indigestion
  • Chest pain
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Side effect rates for Treximet (sumatriptan / naproxen)

From 1489 clinical trials of Treximet when taken for migraines
  • Dizziness
    4%4%
    2%2%
  • Sleepiness
    3%3%
    2%2%
  • Nausea
    3%3%
    1%1%
  • Chest pain
    3%3%
    1%1%
  • Jaw / neck preessure
    3%3%
    1%1%
  • Burning or prickling sensation
    2%2%
    1%1%
  • Indigestion
    2%2%
    1%1%
  • Dry mouth
    2%2%
    1%1%
0%
10%
20%
30%
40%
50%
60%
70%
80%
Where we got our data »

The placebo bar shows how common a side effect was for people taking a sugar pill instead of Treximet.

Treximet (sumatriptan / naproxen)
Placebo

People taking Treximet felt side effect more

People taking Treximet felt side effect less

No difference

Risks and Warnings for Treximet (sumatriptan / naproxen)

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    • Higher risk if:
    • History of heart problems
    • High blood pressure
    • High cholesterol
    • Diabetes
    • Being overweight or obese
    • Smoking
    • Women in menopause
    • Men over 40
    • family history of heart disease

    Some people taking Treximet (sumatriptan / naproxen) have had temporary chest pain, pressure, and tightness. These symptoms are caused by heart vessels being constricted/tightened. Before starting Treximet (sumatriptan / naproxen), people who have coronary artery disease, or are more likely to have it, should talk to their doctor about having a heart health assessment.

    This is a black box warning. The FDA requires this warning when there is a significant risk of serious or life-threatening effects that anyone taking the drug should consider.

Means that some groups have a high risk of experiencing this side effect

Common concerns from people taking Treximet (sumatriptan / naproxen)

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Food
  • Can take with or without food.
Kidneys and liver
  • Treximet (sumatriptan / naproxen) can cause damage to your kidneys. Let your doctor know if you have kidney problems.