Trintellix
(vortioxetine)
Treats depression.
Our bottom line
Trintellix (vortioxetine) causes less sexual side-effects, but more nausea than other antidepressants that work similarly.
- Drug class: Mental health
- Rx status: Prescription only
- Generic status: No lower cost generic available
Upsides
- May improve memory.
- Affects your sex drive less than similar antidepressants.
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What to expect from Trintellix, on one page
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19Downsides
- It may take several weeks before you feel the full effects of Trintellix (vortioxetine).
- Available as a branded product only and is more expensive than other medicines that work similarly.
- Stomach issues, particularly nausea, can be persistent for some people.
- More likely to interact with other medicines compared to other antidepressants.
- Stopping Trintellix (vortioxetine) suddenly puts you at greater risk of side effects.
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What to expect from Trintellix, on one page
Download Fact SheetTrintellix (vortioxetine) is a selective serotonin reuptake inhibitor (SSRI). It increases the serotonin in the brain to regulate mood.
- Drug class: Mental health
- Rx status: Prescription only
- Generic status: No lower cost generic available
Used for
Dosage forms
- Pill
Prices and coupons
Skip prices section. Skip to what to expect section.- Kroger PharmacyGet free coupon$356.69
- Get free coupon
$356.70
What to expect when you take Trintellix (vortioxetine) for Depression
Skip what to expect section. Skip to side effects section.- First few hoursHoursFirst few daysDaysFirst few weeksWeeksFirst few monthsMonths
- Effectiveness
- Starts to kick inFull effects
- First few hoursHoursFirst few daysDaysFirst few weeksWeeksFirst few monthsMonths
- Possible side effects
- Nausea
- Constipation
- Vomiting
- Dry mouth
- Low sex drive (males)
- Dizziness
Side effect rates for Trintellix (vortioxetine)
- Nausea32%32%9%9%
- Dizziness9%9%6%6%
- Dry mouth8%8%6%6%
- Diarrhea7%7%6%6%
- Constipation6%6%3%3%
- Vomiting6%6%1%1%
- Low sex drive (males)5%5%2%2%
- Abnormal dreams3%3%1%1%
- Itching3%3%1%1%
The placebo bar shows how common a side effect was for people taking a sugar pill instead of Trintellix.
People taking Trintellix felt side effect more
People taking Trintellix felt side effect less
Risks and Warnings for Trintellix (vortioxetine)
Skip risks section. Skip to common concerns section.- Higher risk if:
- › Age 24 years or younger
Trintellix (vortioxetine) may increase the risk of suicidal thoughts or behavior. Watch for worsening depression or any unusual changes in mood, especially during the first few months of treatment or after the dose changes. Talk to your doctor right away if this happens. Trintellix (vortioxetine) is not approved for use in children under 18.
This is a black box warning. The FDA requires this warning when there is a significant risk of serious or life-threatening effects that anyone taking the drug should consider.
Common concerns from people taking Trintellix (vortioxetine)
Final section. Do you want to return to drug navigation?- Worth itSome hassleReviewed Trintellixon 3/5/2018They offer discounts on their website along with coupons. It is $12 or so a month for me.19WomanA year or soWould rather not say
- Worth itBig hassleReviewed Trintellixon 8/17/2017It is the best anti-depressant I have ever taken but the cost is outrageous. Hard to believe is cost over $300.00 a month. That hurts being on SSDI.60ManTwo years or moreDepression
- Not worth itLow hassleReviewed Trintellixon 4/11/2017Not worth the cost36ManA couple weeksDepression
- More likely to interact with other medicines compared to other antidepressants.
- Take with food and/or at night to reduce nausea, diarrhea, or gas.
- Worth itSome hassleReviewed Trintellixon 6/10/2017Take with food. Absolutely helped me with my fatigue that I had the entire time taking Effexor.43WomanA few monthsDepression
- Worth itLow hassleReviewed Trintellixon 9/24/2017Take with a little food before sleep, like all antidepressants, give it 4-6 weeks and get up to 10 mg to start seeing effects25ManA few monthsDepression
- Worth itLow hassleReviewed Trintellixon 8/9/2017I take it before I go to sleep. Not sure if it has any effect on my alertness.20WomanA year or soDepression
- Not worth itBig hassleReviewed Trintellixon 3/21/2017I couldn't sleep with this drug, it killed my sex drive and I had eye pain and nausea within the hour every day after taking it.29ManA month or soDepression