Trintellix

(vortioxetine)

3.7/ 5 average rating with 19 reviewsforTrintellix
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Treats depression.

Skip Upsides & Downsides section. Skip to side effects section.

Our bottom line

Trintellix (vortioxetine) causes less sexual side-effects, but more nausea than other antidepressants that work similarly.

Lowest price near you
  • Price before coupon
    $449.99
  • Lowest price with coupon
    $351.44
  • Savings
    22%
Quick facts about Trintellix
  • Drug class: Mental health
  • Rx status: Prescription only
  • Generic status: No lower cost generic available

Upsides

  • May improve memory.
  • Affects your sex drive less than similar antidepressants.
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What to expect from Trintellix, on one page

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People’s experience with Trintellix

19reviews so far. What do you think?

Downsides

  • It may take several weeks before you feel the full effects of Trintellix (vortioxetine).
  • Available as a branded product only and is more expensive than other medicines that work similarly.
  • Stomach issues, particularly nausea, can be persistent for some people.
  • More likely to interact with other medicines compared to other antidepressants.
  • Stopping Trintellix (vortioxetine) suddenly puts you at greater risk of side effects.
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What to expect from Trintellix, on one page

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How it works

Trintellix (vortioxetine) is a selective serotonin reuptake inhibitor (SSRI). It increases the serotonin in the brain to regulate mood.

Quick facts about Trintellix
  • Drug class: Mental health
  • Rx status: Prescription only
  • Generic status: No lower cost generic available

Used for

Dosage forms

  • Pill
People’s experience with Trintellix

19reviews so far. What do you think?

Prices and coupons

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What to expect when you take Trintellix (vortioxetine) for Depression

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  • First few hoursHours
    First few daysDays
    First few weeksWeeks
    First few monthsMonths
  • Effectiveness
  • Starts to kick in
    Full effects
  • First few hoursHours
    First few daysDays
    First few weeksWeeks
    First few monthsMonths
  • Possible side effects
  • Nausea
  • Constipation
  • Vomiting
  • Dry mouth
  • Low sex drive (males)
  • Dizziness
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Side effect rates for Trintellix (vortioxetine)

From 2066 clinical trials of Trintellix when taken for depression (20 mg qd)
  • Nausea
    32%32%
    9%9%
  • Dizziness
    9%9%
    6%6%
  • Dry mouth
    8%8%
    6%6%
  • Diarrhea
    7%7%
    6%6%
  • Constipation
    6%6%
    3%3%
  • Vomiting
    6%6%
    1%1%
  • Low sex drive (males)
    5%5%
    2%2%
  • Abnormal dreams
    3%3%
    1%1%
  • Itching
    3%3%
    1%1%
0%
10%
20%
30%
40%
50%
60%
70%
80%
Where we got our data »

The placebo bar shows how common a side effect was for people taking a sugar pill instead of Trintellix.

Trintellix (vortioxetine)
Placebo

People taking Trintellix felt side effect more

People taking Trintellix felt side effect less

No difference

Risks and Warnings for Trintellix (vortioxetine)

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    • Higher risk if:
    • Age 24 years or younger

    Trintellix (vortioxetine) may increase the risk of suicidal thoughts or behavior. Watch for worsening depression or any unusual changes in mood, especially during the first few months of treatment or after the dose changes. Talk to your doctor right away if this happens. Trintellix (vortioxetine) is not approved for use in children under 18.

    This is a black box warning. The FDA requires this warning when there is a significant risk of serious or life-threatening effects that anyone taking the drug should consider.

Means that some groups have a high risk of experiencing this side effect

Common concerns from people taking Trintellix (vortioxetine)

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Price
  • Worth it
    Some hassle
    Reviewed Trintellixon 3/5/2018They offer discounts on their website along with coupons. It is $12 or so a month for me.
    19
    Woman
    A year or so
    Would rather not say
  • Worth it
    Big hassle
    Reviewed Trintellixon 8/17/2017It is the best anti-depressant I have ever taken but the cost is outrageous. Hard to believe is cost over $300.00 a month. That hurts being on SSDI.
    60
    Man
    Two years or more
    Depression
  • Not worth it
    Low hassle
    Reviewed Trintellixon 4/11/2017Not worth the cost
    36
    Man
    A couple weeks
    Depression
Interactions
  • More likely to interact with other medicines compared to other antidepressants.
Food
  • Take with food and/or at night to reduce nausea, diarrhea, or gas.
  • Worth it
    Some hassle
    Reviewed Trintellixon 6/10/2017Take with food. Absolutely helped me with my fatigue that I had the entire time taking Effexor.
    43
    Woman
    A few months
    Depression
Sleep
  • Worth it
    Low hassle
    Reviewed Trintellixon 9/24/2017Take with a little food before sleep, like all antidepressants, give it 4-6 weeks and get up to 10 mg to start seeing effects
    25
    Man
    A few months
    Depression
  • Worth it
    Low hassle
    Reviewed Trintellixon 8/9/2017I take it before I go to sleep. Not sure if it has any effect on my alertness.
    20
    Woman
    A year or so
    Depression
  • Not worth it
    Big hassle
    Reviewed Trintellixon 3/21/2017I couldn't sleep with this drug, it killed my sex drive and I had eye pain and nausea within the hour every day after taking it.
    29
    Man
    A month or so
    Depression