Trintellix
(vortioxetine)
Treats depression.
Our bottom line
Trintellix (vortioxetine) causes less sexual side-effects, but more nausea than other antidepressants that work similarly.
- Drug class: Mental health
- Rx status: Prescription only
- Generic status: No lower cost generic available
Upsides
- May improve memory.
- Affects your sex drive less than similar antidepressants.
What to expect from Trintellix, on one page
Downsides
- It may take several weeks before you feel the full effects of Trintellix (vortioxetine).
- Available as a branded product only and is more expensive than other medicines that work similarly.
- Stomach issues, particularly nausea, can be persistent for some people.
- More likely to interact with other medicines compared to other antidepressants.
- Stopping Trintellix (vortioxetine) suddenly puts you at greater risk of side effects.
What to expect from Trintellix, on one page
Trintellix (vortioxetine) is a selective serotonin reuptake inhibitor (SSRI). It increases the serotonin in the brain to regulate mood.
- Drug class: Mental health
- Rx status: Prescription only
- Generic status: No lower cost generic available
Used for
Dosage forms
- Pill
Prices and coupons
Skip prices section. Skip to what to expect section.- Get free discount$393.06
- Kroger PharmacyGet free coupon$393.06
What to expect when you take Trintellix (vortioxetine) for Depression
Skip what to expect section. Skip to side effects section.- First few hoursHoursFirst few daysDaysFirst few weeksWeeksFirst few monthsMonths
- Effectiveness
- Starts to kick inFull effects
- First few hoursHoursFirst few daysDaysFirst few weeksWeeksFirst few monthsMonths
- Possible side effects
- Nausea
- Constipation
- Vomiting
- Dry mouth
- Low sex drive (males)
- Dizziness
It can take time for a drug to start working, or for some side effects to go away.
Source: FDA product label and Iodine pharmacistsSide effect rates for Trintellix (vortioxetine)
- Nausea32%32%9%9%
- Dizziness9%9%6%6%
- Dry mouth8%8%6%6%
- Diarrhea7%7%6%6%
- Constipation6%6%3%3%
- Vomiting6%6%1%1%
- Low sex drive (males)5%5%2%2%
- Abnormal dreams3%3%1%1%
- Itching3%3%1%1%
The placebo bar shows how common a side effect was for people taking a sugar pill instead of Trintellix.
People taking Trintellix felt side effect more
People taking Trintellix felt side effect less
Risks and Warnings for Trintellix (vortioxetine)
Skip risks section. Skip to common concerns section.- Higher risk if:
- › Age 24 years or younger
Trintellix (vortioxetine) may increase the risk of suicidal thoughts or behavior. Watch for worsening depression or any unusual changes in mood, especially during the first few months of treatment or after the dose changes. Talk to your doctor right away if this happens. Trintellix (vortioxetine) is not approved for use in children under 18.
This is a black box warning. The FDA requires this warning when there is a significant risk of serious or life-threatening effects that anyone taking the drug should consider.
Common concerns from people taking Trintellix (vortioxetine)
Final section. Do you want to return to drug navigation?- Worth itLow hassleReviewed Trintellixon 2/6/2021Best med for MDD, but the price causes a different kind of depression...37WomanA few monthsDepression
- Worth itSome hassleReviewed Trintellixon 1/5/2021Just the cost. But a great med for mdd58WomanTwo years or moreDepression
- Worth itLow hassleReviewed Trintellixon 9/5/2020I've been batteling depression,anxiety and insomnia for about 12 yrs. I have tried countless number of medications and NOTHING worked! Even went through a year of ECT(shock therapy)it helped in a sense of not waking up with panic attacks and the suicide attempts but I still felt dead on the inside with bad anxiety. Went through years of self medicading myself with drugs because I lost hope that I will ever find the right medication then I found Trintellix..my 2nd chance@life.43WomanA month or soDepression
- More likely to interact with other medicines compared to other antidepressants.
- Take with food and/or at night to reduce nausea, diarrhea, or gas.
- Worth itLow hassleReviewed Trintellixon 10/23/2020I take after breakfast and have not experienced any side effects. My insurance is good and it's $60 a month. I'll be looking for a discount card to see if I can get it cheaper. I think it's helping with some of the brain fog and feelings of being overwhelmed I've been suffering with recently.49WomanA couple weeksDepression
- Not sureSome hassleReviewed Trintellixon 8/18/2019Take with food at betime. I have had trouble with irritability. Weakness. Tired. But am going from paxil to trintillex. So unsure whats is giving which problem.53ManA few monthsDepression
- Not worth itBig hassleReviewed Trintellixon 8/8/2019Nausea was present most of the day. If you don't eat a large breakfast with the medication, vomiting results. Also experienced excessive tiredness and dizziness on exertion. I have one of the best Health Care plans, but it is not covered and costs about $188 for 30 pills.66WomanA couple weeksDepression
- Worth itLow hassleReviewed Trintellixon 9/24/2017Take with a little food before sleep, like all antidepressants, give it 4-6 weeks and get up to 10 mg to start seeing effects25ManA few monthsDepression
- Worth itLow hassleReviewed Trintellixon 8/9/2017I take it before I go to sleep. Not sure if it has any effect on my alertness.20WomanA year or soDepression
- Not worth itBig hassleReviewed Trintellixon 3/21/2017I couldn't sleep with this drug, it killed my sex drive and I had eye pain and nausea within the hour every day after taking it.29ManA month or soDepression