Trintellix

(vortioxetine)

●●●●●
3.7/ 5 average rating with 19 reviewsforTrintellix
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Treats depression.

Skip Upsides & Downsides section. Skip to side effects section.

Our bottom line

Trintellix (vortioxetine) causes less sexual side-effects, but more nausea than other antidepressants that work similarly.

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Quick facts about Trintellix
  • Drug class: Mental health
  • Rx status: Prescription only
  • Generic status: No lower cost generic available

Upsides

  • May improve memory.
  • Affects your sex drive less than similar antidepressants.
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What to expect from Trintellix, on one page

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People’s experience with Trintellix

19reviews so far. What do you think?

Downsides

  • It may take several weeks before you feel the full effects of Trintellix (vortioxetine).
  • Available as a branded product only and is more expensive than other medicines that work similarly.
  • Stomach issues, particularly nausea, can be persistent for some people.
  • More likely to interact with other medicines compared to other antidepressants.
  • Stopping Trintellix (vortioxetine) suddenly puts you at greater risk of side effects.
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What to expect from Trintellix, on one page

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How it works

Trintellix (vortioxetine) is a selective serotonin reuptake inhibitor (SSRI). It increases the serotonin in the brain to regulate mood.

Quick facts about Trintellix
  • Drug class: Mental health
  • Rx status: Prescription only
  • Generic status: No lower cost generic available

Used for

Dosage forms

  • Pill
People’s experience with Trintellix

19reviews so far. What do you think?

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What to expect when you take Trintellix (vortioxetine) for Depression

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  • First few hoursHours
    First few daysDays
    First few weeksWeeks
    First few monthsMonths
  • Effectiveness
  • Starts to kick in
    Full effects
  • First few hoursHours
    First few daysDays
    First few weeksWeeks
    First few monthsMonths
  • Possible side effects
  • Nausea
  • Constipation
  • Vomiting
  • Dry mouth
  • Low sex drive (males)
  • Dizziness
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Side effect rates for Trintellix (vortioxetine)

From 2066 clinical trials of Trintellix when taken for depression (20 mg qd)
  • Nausea
    32%32%
    9%9%
  • Dizziness
    9%9%
    6%6%
  • Dry mouth
    8%8%
    6%6%
  • Diarrhea
    7%7%
    6%6%
  • Constipation
    6%6%
    3%3%
  • Vomiting
    6%6%
    1%1%
  • Low sex drive (males)
    5%5%
    2%2%
  • Abnormal dreams
    3%3%
    1%1%
  • Itching
    3%3%
    1%1%
0%
10%
20%
30%
40%
50%
60%
70%
80%
Where we got our data »

The placebo bar shows how common a side effect was for people taking a sugar pill instead of Trintellix.

Trintellix (vortioxetine)
Placebo

People taking Trintellix felt side effect more

People taking Trintellix felt side effect less

No difference

Risks and Warnings for Trintellix (vortioxetine)

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    • Higher risk if:
    • › Age 24 years or younger

    Trintellix (vortioxetine) may increase the risk of suicidal thoughts or behavior. Watch for worsening depression or any unusual changes in mood, especially during the first few months of treatment or after the dose changes. Talk to your doctor right away if this happens. Trintellix (vortioxetine) is not approved for use in children under 18.

    This is a black box warning. The FDA requires this warning when there is a significant risk of serious or life-threatening effects that anyone taking the drug should consider.

Means that some groups have a high risk of experiencing this side effect

Common concerns from people taking Trintellix (vortioxetine)

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Price
  • Worth it
    Worked well
    Big hassle
    Reviewed Trintellixon 9/26/2019It is so expensive I have to half meds to take it. It cost $90 with insurance & coupon.
    55
    Woman
    A year or so
    Depression
  • Worth it
    Worked well
    Low hassle
    Reviewed Trintellixon 5/9/2019This is the only medication that has worked for my depression. I have tried countless medications over the past 26 years, and this is the only medication that didn't put me in a physical hell! I have zero side effects & I am so grateful for the freedom finally!!! I take it with my dinner.
    40
    Woman
    A month or so
    Depression
  • Not worth it
    Didn’t work
    Big hassle
    Reviewed Trintellixon 4/3/2019If you do opt to use Trintellix, be sure to obtain the discount card. It was $150 a month even after insurance! On top of that, I found my depression worsening as well as increased anxiety, paranoia, and anger. Mood swings were rough with this one.
    32
    Woman
    A month or so
    Depression
Interactions
  • More likely to interact with other medicines compared to other antidepressants.
Food
  • Take with food and/or at night to reduce nausea, diarrhea, or gas.
  • Not sure
    Worked so-so
    Some hassle
    Reviewed Trintellixon 8/18/2019Take with food at betime. I have had trouble with irritability. Weakness. Tired. But am going from paxil to trintillex. So unsure whats is giving which problem.
    53
    Man
    A few months
    Depression
  • Not worth it
    Didn’t work
    Big hassle
    Reviewed Trintellixon 8/8/2019Nausea was present most of the day. If you don't eat a large breakfast with the medication, vomiting results. Also experienced excessive tiredness and dizziness on exertion. I have one of the best Health Care plans, but it is not covered and costs about $188 for 30 pills.
    66
    Woman
    A couple weeks
    Depression
  • Not sure
    Worked so-so
    Some hassle
    Reviewed Trintellixon 5/2/2019Make sure you stomach has food in it for about 20 minutes then take the medicine. The first few times I took it, I threw it up in about 15 minutes. After taking it with food I. My stimach, I did not vomit.
    46
    Man
    A couple weeks
    Depression
Sleep
  • Worth it
    Low hassle
    Reviewed Trintellixon 9/24/2017Take with a little food before sleep, like all antidepressants, give it 4-6 weeks and get up to 10 mg to start seeing effects
    25
    Man
    A few months
    Depression
  • Worth it
    Worked well
    Low hassle
    Reviewed Trintellixon 8/9/2017I take it before I go to sleep. Not sure if it has any effect on my alertness.
    20
    Woman
    A year or so
    Depression
  • Not worth it
    Didn’t work
    Big hassle
    Reviewed Trintellixon 3/21/2017I couldn't sleep with this drug, it killed my sex drive and I had eye pain and nausea within the hour every day after taking it.
    29
    Man
    A month or so
    Depression