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Dissolves gallbladder stones.

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Our bottom line

Actigall (Ursodiol) is a decent way to get rid of gallstones if surgery isn't an option for you.

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Quick facts about Urso
  • Drug class: Renal
  • Rx status: Prescription only
  • Generic status: Lower-cost generic available (ursodiol)


  • Helps dissolve gallbladder stones without needing to have surgery.
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  • Can take long time for gallstones to be fully dissolved.
  • May not work depending on the initial size of the gallstone.
  • Often causes upset stomach.
  • Can be pricey.
How it works

Actigall (Ursodiol) helps dissolve gallstones by lowering the amount of cholesterol your body makes and absorbs. Lower cholesterol prevents gallstones from getting bigger and allows your body to get rid of the gallstone over time.

Quick facts about Urso
  • Drug class: Renal
  • Rx status: Prescription only
  • Generic status: Lower-cost generic available (ursodiol)

Used for

Dosage forms

  • Pill
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Prices and coupons

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Side effect rates for Actigall (Ursodiol)

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These are side effects of Actigall (Ursodiol) reported to the FDA by people taking it, and by doctors and pharmacists.
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Risks and Warnings for Actigall (Ursodiol)

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  • Bile acid sequestering agents (like Cholestyramine and Colestipol) and aluminum-based antacids can interfere with how well Actigall (Ursodiol) works by not letting it be absorbed by your body. Estrogens, oral contraceptives, and clofibrate (and perhaps other lipid-lowering drugs) can cause gallstones to be made and work against the effectiveness of Actigall (Ursodiol).

Common concerns from people taking Actigall (Ursodiol)

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Research studies with animals haven’t found a risk to unborn babies, but it hasn’t been properly studied in humans.

Tip: Always talk with your doctor before you take any medication while pregnant.
FDA pregnancy category for Urso
BProbably safe
  • Can be pricey.
  • Take with food to lessen upset stomach.