Vimovo

(naproxen / esomeprazole)

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Treats arthritis pain while also protecting your stomach.

Skip Upsides & Downsides section. Skip to side effects section.

Our bottom line

While naproxen in Vimovo (naproxen / esomeprazole) provides good arthritis pain relief, it can also cause stomach ulcers. Vimovo (naproxen / esomeprazole) includes esomeprazole that lowers your risk.

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  • Lowest price with coupon
    $2473.37
Quick facts about Vimovo
  • Drug class: musculoskeletal
  • Rx status: Prescription only
  • Generic status: No lower cost generic available

Upsides

  • Works well to treat your arthritis pain.
  • It lasts longer than other NSAIDS so you don't have to take it as often.
  • Your stomach is more protected from ulcers than if you were taking an NSAID alone.
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What to expect from Vimovo, on one page

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Downsides

  • Vimovo (naproxen / esomeprazole) needs to be taken with food or milk to avoid getting an upset stomach.
  • It can cause serious complications like stomach bleeding and kidney problems if taken for a long period of time.
  • You should avoid alcohol while on Vimovo (naproxen / esomeprazole) since it can increase your risk of stomach issues.
  • If you have an allergy to aspirin, ibuprofen or other NSAIDs, you may not be able to use Vimovo (naproxen / esomeprazole). Let your doctor know of your allergy.
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What to expect from Vimovo, on one page

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How it works

Vimovo (naproxen / esomeprazole) is a combination medication (naproxen/esomeprazole). Naproxen (an NSAID) gets rid of your arthritis pain while esomeprazole protects your stomach from developing ulcers caused by naproxen.

Quick facts about Vimovo
  • Drug class: musculoskeletal
  • Rx status: Prescription only
  • Generic status: No lower cost generic available
Tried Vimovo? Write a review!

Prices and coupons

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What to expect when you take Vimovo (naproxen / esomeprazole) for Arthritis pain

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  • First few hoursHours
    First few daysDays
    First few weeksWeeks
    First few monthsMonths
  • Effectiveness
  • Starts to kick in
    Full effects
  • First few hoursHours
    First few daysDays
    First few weeksWeeks
    First few monthsMonths
  • Possible side effects
  • Upper abdominal pain
  • Common cold
  • Diarrhea
  • Passing gas
  • Headache
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Side effect rates for Vimovo (naproxen / esomeprazole)

From 736 clinical trials of Vimovo when taken for null (500 mg/20 mg vimovo twice daily vs. placebo)
  • Diarrhea
    6%6%
    4%4%
  • Upper abdominal pain
    4%4%
    3%3%
  • Constipation
    4%4%
    1%1%
  • Dizziness
    3%3%
    2%2%
  • Swelling in limbs
    3%3%
    1%1%
0%
10%
20%
30%
40%
50%
60%
70%
80%
Where we got our data »

The placebo bar shows how common a side effect was for people taking a sugar pill instead of Vimovo.

Vimovo (naproxen / esomeprazole)
Placebo

People taking Vimovo felt side effect more

People taking Vimovo felt side effect less

No difference

Risks and Warnings for Vimovo (naproxen / esomeprazole)

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    • Higher risk if:
    • Recent heart surgery
    • Recent heart attack
    • Taking high doses of NSAIDs
    • Taking NSAIDs for a long period of time

    Vimovo (naproxen / esomeprazole) raises your risk of having a heart attack or stroke that can lead to death. This risk may happen early in treatment and the risk is higher the longer you use it. Do not use Vimovo (naproxen / esomeprazole) for longer than directed. Ask your doctor about the symptoms of serious heart problems that you should look out for.

    This is a black box warning. The FDA requires this warning when there is a significant risk of serious or life-threatening effects that anyone taking the drug should consider.

Means that some groups have a high risk of experiencing this side effect

Common concerns from people taking Vimovo (naproxen / esomeprazole)

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Alcohol
  • You should avoid alcohol while on Vimovo (naproxen / esomeprazole) since it can increase your risk of stomach issues.
Food
  • If you are also taking blood thinners, Vimovo (naproxen / esomeprazole) may make you bleed more easily. Be careful and avoid injury.
  • Vimovo (naproxen / esomeprazole) needs to be taken with food or milk to avoid getting an upset stomach.
Kidneys and liver
  • Vimovo (naproxen / esomeprazole) can cause kidney injuries that can happen at any time during treatment. Talk to your doctor about what to look for. Let your doctor know if you have a history of kidney or liver problems, heart problems, or if you've been on water pills or medications for your kidneys. If you do develop kidney problems, your doctor will stop Vimovo (naproxen / esomeprazole). Kidney function usually goes back to normal once you stop Vimovo (naproxen / esomeprazole).
Pain
  • Works well to treat your arthritis pain.