Vytorin

(Ezetimibe / Simvastatin)

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3.3/ 5 average rating with 99 reviewsforVytorin
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Lowers cholesterol.

Skip Upsides & Downsides section. Skip to side effects section.

Our bottom line

Vytorin is expensive and is no more effective than simvastatin by itself.

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Quick facts about Vytorin
  • Drug class: Cardiovascular
  • Rx status: Prescription only
  • Generic status: No lower cost generic available

Upsides

  • A 2-in-1 cholesterol-lowering combination medicine.
  • Lowers "bad" cholesterol (LDL) and raises "good" cholesterol (HDL) in people who have trouble doing this through diet and exercise.
People’s experience with Vytorin

99reviews so far. What do you think?

Downsides

  • In clinical studies, simvastatin/ezetimibe hasn't controlled cholesterol better than simvastatin alone.
  • There's no generic available, so it can be expensive.
How it works

Vytorin is a combination cholesterol-lowering medicine. Simvastatin prevents your body from making "bad" cholesterol (LDL) while raising "good" cholesterol (HDL). Ezetimibe prevents cholesterol absorption in your intestines.

Quick facts about Vytorin
  • Drug class: Cardiovascular
  • Rx status: Prescription only
  • Generic status: No lower cost generic available

Used for

Dosage forms

  • Pill
People’s experience with Vytorin

99reviews so far. What do you think?

Prices and coupons

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Side effect rates for Vytorin (Ezetimibe / Simvastatin)

  • Headache
    6%6%
  • Any side effect
    5%5%
    2%2%
  • Increased ALT
    4%4%
  • Myalgia
    4%4%
  • Upper respiratory tract infection
    4%4%
  • Myalgia
    4%4%
    2%2%
  • Diarrhea
    3%3%
  • Influenza
    2%2%
    1%1%
  • Pain in extremity
    2%2%
    1%1%
0%
10%
20%
30%
40%
50%
60%
70%
80%
Where we got our data »

The placebo bar shows how common a side effect was for people taking a sugar pill instead of Vytorin.

Vytorin (Ezetimibe / Simvastatin)
Placebo

People taking Vytorin felt side effect more

People taking Vytorin felt side effect less

No difference

Risks and Warnings for Vytorin (Ezetimibe / Simvastatin)

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    • Higher risk if:
    • › Asian patients taking high-dose niacin

    People on Vytorin (Ezetimibe / Simvastatin) have reported muscle pain which may lead to muscle breakdown and kidney damage, especially in people of Asian ancestry who are also taking niacin. This has been very rare. Talk to your doctor if you suddenly develop muscle pain and a fever and you don't know why.

Pharmacist Q&A

Vytorin (Ezetimibe / Simvastatin) questions for

Frequently Asked Questions

Adults with homozygous familial hypercholesterolemia, in combination with other lipid-lowering treatments (e.g., LDL apheresis) or if such treatments are unavailable.

Who is this drug for?

Adults with homozygous familial hypercholesterolemia, in combination with other lipid-lowering treatments (e.g., LDL apheresis) or if such treatments are unavailable.

Common concerns from people taking Vytorin (Ezetimibe / Simvastatin)

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Pregnancy

Research studies with real people or animals found harmful effects on unborn babies. If you’re pregnant, the risks to your unborn baby outweigh the benefits.

See the FDA package insertSee pregnancy safe medications
Tip: Always talk with your doctor before you take any medication while pregnant.
FDA pregnancy category for Vytorin
XUnsafe
Kidneys and liver
  • People on Vytorin (Ezetimibe / Simvastatin) have reported muscle pain which may lead to muscle breakdown and kidney damage, especially in people of Asian ancestry who are also taking niacin. This has been very rare. Talk to your doctor if you suddenly develop muscle pain and a fever and you don't know why.
Sleep
  • Worth it
    Worked so-so
    Some hassle
    Reviewed Vytorinon 9/20/2016Take medication at sleep time after 6 months cholesterol and triglycerides did improve
    62
    Man
    High cholesterol