Zanaflex

(tizanidine)

4.3/ 5 average rating with 26 reviewsforZanaflex
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Relaxes your muscles.

Skip Upsides & Downsides section. Skip to side effects section.

Our bottom line

Zanaflex (tizanidine) isn't a first-choice treatment for muscle spasticity. Try other options before using this.

Lowest price near you
  • Price before coupon
    $51.84
  • Lowest price with coupon
    $14.09
    73% savings
Quick facts about Zanaflex
  • Drug class: Musculoskeletal
  • Rx status: Prescription only
  • Generic status: Lower-cost generic available (tizanidine)

Upsides

  • Relieves muscle spasticity.
  • Available as a generic.
  • Available in a tablet or capsule form. It also comes in a capsule that can be opened and sprinkled in applesauce for people that can't swallow pills.
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What to expect from Zanaflex, on one page

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People’s experience with Zanaflex

26reviews so far. What do you think?

Downsides

  • This isn't a first-choice muscle relaxing medication. Other drugs work better and have fewer side effects.
  • Takes over an hour to kick in and only lasts 3 to 6 hours.
  • Zanaflex (tizanidine) can lower blood pressure, so be careful if you are already on a blood pressure medication.
  • Need to be consistent every day in taking this with or without food.
  • Elderly individuals have more side effects when taking Zanaflex (tizanidine).
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What to expect from Zanaflex, on one page

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How it works

Zanaflex (tizanidine) is an alpha2-adrenergic agonist that works in the nervous system to calm down muscle spasticity.

Quick facts about Zanaflex
  • Drug class: Musculoskeletal
  • Rx status: Prescription only
  • Generic status: Lower-cost generic available (tizanidine)

Dosage forms

  • Pill
People’s experience with Zanaflex

26reviews so far. What do you think?

Prices and coupons

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What to expect when you take Zanaflex (tizanidine) for Muscle spasticity

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  • First few hoursHours
    First few daysDays
    First few weeksWeeks
    First few monthsMonths
  • Effectiveness
  • Full effects
  • First few hoursHours
    First few daysDays
    First few weeksWeeks
    First few monthsMonths
  • Possible side effects
  • Sleepiness
  • Weakness
  • Dry mouth
  • Dizziness
  • Low blood pressure
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Side effect rates for Zanaflex (tizanidine)

From 525 clinical trials of Zanaflex when taken for muscle spasticity (multiple doses)
  • Dry mouth
    49%49%
    10%10%
  • Sleepiness
    48%48%
    10%10%
  • Weakness
    41%41%
    16%16%
  • Dizziness
    16%16%
    4%4%
  • Urinary tract infection
    10%10%
    7%7%
  • General infection
    6%6%
    5%5%
  • Liver test abnormality
    6%6%
    2%2%
  • Constipation
    4%4%
    1%1%
  • Vomiting
    3%3%
  • Speech disorder
    3%3%
  • Blurred vision
    3%3%
    1%1%
  • Urinary frequency
    3%3%
    2%2%
  • Flu syndrome
    3%3%
    2%2%
  • Involuntary muscle movement
    3%3%
  • Nervousness
    3%3%
    1%1%
  • Sore throat
    3%3%
    1%1%
  • Hay fever
    3%3%
    2%2%
0%
10%
20%
30%
40%
50%
60%
70%
80%
Where we got our data »

The placebo bar shows how common a side effect was for people taking a sugar pill instead of Zanaflex.

Zanaflex (tizanidine)
Placebo

People taking Zanaflex felt side effect more

People taking Zanaflex felt side effect less

No difference

Risks and Warnings for Zanaflex (tizanidine)

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    • Higher risk if:
    • Taking maximum doses of Zanaflex (tizanidine)

    Zanaflex (tizanidine) can damage your liver. You'll need to get blood tests done to check how your liver is functioning if you're taking this regularly.

Pharmacist Q&A

Zanaflex (tizanidine) questions for

Frequently Asked Questions

This medication treats muscle spasms.

Who is this drug for?

This medication treats muscle spasms.

Common concerns from people taking Zanaflex (tizanidine)

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Food
  • Can be taken with or without food, but you need to be consistent since food affects how the medication is absorbed and works.
  • Need to be consistent every day in taking this with or without food.
Kidneys and liver
  • Worth it
    Some hassle
    Reviewed Zanaflexon 3/30/2017Watch out for signs of liver toxicity. They resolve quickly when use is topped, but can be somewhat unpleasant.
    24
    Man
    A month or so
    Headache (long-term)
Pain
  • Worth it
    Low hassle
    Reviewed ZanaflexI took it for back pain, the pain is still there and it has not helped the pain, but I have not had a anxiety attack! This is a big thing for me as I have had them every day for years! It does not help me sleep but I am not tired.
    47
    Woman
    A month or so
Sleep
  • Taking Zanaflex (tizanidine) can make you feel sleepy and dizzy, especially if you're taking other medications that can also make you feel sleepy, or if you're taking recreational drugs or drinking too much alcohol. Avoid driving or doing other tasks that require concentration until you know how this medication affects you.
  • Can cause dizziness, fatigue, drowsiness, and dry mouth.
  • Worth it
    Low hassle
    Reviewed Zanaflexon 1/2/2017does cause drowsiness but since I tend to suffer from insomnia, works great at bedtime. It also works to help control breakthrough migraines.
    53
    Woman
    Spasticity