Zestoretic

(Lisinopril / Hydrochlorothiazide)

3.4/ 5 average rating with 294 reviewsforZestoretic
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Lowers blood pressure.

Skip Upsides & Downsides section. Skip to side effects section.

Our bottom line

Lisinopril/hydrochlorothiazide is a good 2-in-1 blood pressure-lowering medicine that protects kidney function.

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    $4.03
Quick facts about Zestoretic
  • Drug class: Cardiovascular
  • Rx status: Prescription only
  • Generic status: Lower-cost generic available (lisinopril / hydrochlorothiazide)

Upsides

  • Combination medicine for people with high blood pressure. Doctors might prescribe it when you need more than one medicine to control your blood pressure.
  • The two drugs in Lisinopril/hydrochlorothiazide work together to lower blood pressure, remove extra water from your body, and lower your risk of heart attack and stroke.
  • Protects kidney function, which is especially useful for people with diabetes or mild-to-moderate kidney disease.
  • Recommended for anyone with heart failure since it lowers the risk of death and further damage to your heart.
People’s experience with Zestoretic

294reviews so far. What do you think?

Downsides

  • Comes in fixed dosage strengths, so it's harder for your doctor to adjust your dose.
  • Up to 1 in 10 people can get a dry cough with this medicine. It ranges from a mild tickle in the throat to a persistent hacking cough.
  • Makes you urinate more often.
  • Doesn't work as well in people with severe kidney problems.
  • Requires a yearly blood test to see how the medicine is affecting your body.
  • Not safe to use if you're pregnant.
How it works

Lisinopril/hydrochlorothiazide is a combination medicine. Lisinopril (an ACE inhibitor) lowers blood pressure by making blood vessels relax. Hydrochlorothiazide (a diuretic or water pill) lowers blood pressure and swelling by removing extra fluid from your body.

Quick facts about Zestoretic
  • Drug class: Cardiovascular
  • Rx status: Prescription only
  • Generic status: Lower-cost generic available (lisinopril / hydrochlorothiazide)

Dosage forms

  • Pill
People’s experience with Zestoretic

294reviews so far. What do you think?

Prices and coupons

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Side effect rates for Zestoretic (Lisinopril / Hydrochlorothiazide)

From 1137 clinical trials of Zestoretic when taken for high blood pressure (tablet)
  • Dizziness
    8%8%
    2%2%
  • Headache
    5%5%
    2%2%
  • Cough
    4%4%
    1%1%
  • Fatigue
    4%4%
    1%1%
  • Orthostatic Effects
    3%3%
    1%1%
  • Diarrhea
    3%3%
    2%2%
  • Nausea
    2%2%
    2%2%
  • Upper Respiratory Infection
    2%2%
  • Muscle Cramps
    2%2%
  • Asthenia
    2%2%
    1%1%
  • Paresthesia
    2%2%
0%
10%
20%
30%
40%
50%
60%
70%
80%
Where we got our data »

The placebo bar shows how common a side effect was for people taking a sugar pill instead of Zestoretic.

Zestoretic (Lisinopril / Hydrochlorothiazide)
Placebo

People taking Zestoretic felt side effect more

People taking Zestoretic felt side effect less

No difference

Risks and Warnings for Zestoretic (Lisinopril / Hydrochlorothiazide)

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    • Higher risk if:
    • Women of childbearing age

    Zestoretic (Lisinopril / Hydrochlorothiazide) can cause birth defects or death to a fetus. If you are pregnant or considering having a baby, talk to your doctor about alternative medicines.

    This is a black box warning. The FDA requires this warning when there is a significant risk of serious or life-threatening effects that anyone taking the drug should consider.

Means that some groups have a high risk of experiencing this side effect

Pharmacist Q&A

Zestoretic (Lisinopril / Hydrochlorothiazide) questions for

Frequently Asked Questions

This medication treats hypertension (high blood pressure).

Who is this drug for?

This medication treats hypertension (high blood pressure).

Common concerns from people taking Zestoretic (Lisinopril / Hydrochlorothiazide)

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Pregnancy

Research studies with real people found harmful effects on unborn babies, but the benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

Tip: Always talk with your doctor before you take any medication while pregnant.
FDA pregnancy category for Zestoretic
DWeigh risks vs. benefits
Kidneys and liver
  • Zestoretic (Lisinopril / Hydrochlorothiazide) can cause severe allergic reactions, including death, to patients who required certain types of kidney dialysis. Talk to your prescriber if you are undergoing dialysis to discuss possible alternative medications.
  • Zestoretic (Lisinopril / Hydrochlorothiazide) can cause kidney damage, especially if you already have a history of kidney disease. Talk to your doctor to discuss possible alternatives if this is a concern.
  • Requires routine blood tests to check kidney function.
  • Protects kidney function, which is especially useful for people with diabetes or mild-to-moderate kidney disease.