Zofran

(ondansetron)

3.6/ 5 average rating with 366 reviewsforZofran
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Helps prevent nausea and vomiting.

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Our bottom line

Zofran (ondansetron) works well to prevent nausea and vomiting. It's available in different forms that you don't have to swallow in case you can't keep anything down.

Lowest price near you
  • Lowest price with coupon
    $341.34
Quick facts about Zofran
  • Drug class: Gastrointestinal
  • Rx status: Prescription only
  • Generic status: Lower-cost generic available (ondansetron)

Upsides

  • Zofran (ondansetron) comes in many different forms that you don't have to swallow, such as a film that goes on the tongue or a dissolving pill.
  • Zofran (ondansetron) is fast-acting and starts working within 30 minutes.
  • Unlike some other nausea medicines, the side effects for Zofran (ondansetron) are relatively mild.
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What to expect from Zofran, on one page

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People’s experience with Zofran

366reviews so far. What do you think?

Downsides

  • Zofran (ondansetron) doesn't treat nausea and vomiting that's already happening. It only works to prevent future episodes.
  • High doses of Zofran (ondansetron) can cause problems with heart rhythm if you're at risk.
  • If you are also taking antidepressants, you are at higher risk of developing a dangerous condition called serotonin syndrome. Talk with your doctor about your risks.
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What to expect from Zofran, on one page

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How it works

Zofran (ondansetron) is an anti-nausea medicine that works by blocking the activation of nerves that cause a nausea and vomiting response.

Quick facts about Zofran
  • Drug class: Gastrointestinal
  • Rx status: Prescription only
  • Generic status: Lower-cost generic available (ondansetron)

Used for

  • Nausea and vomiting due to cancer medicines
  • Prevention of nausea and vomiting due to radiation therapy and after surgery
  • Severe nausea and vomiting in pregnancy

Dosage forms

  • Pill
  • Disintegrating tablet
  • Liquid
  • Sublingual film
People’s experience with Zofran

366reviews so far. What do you think?

Prices and coupons

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What to expect when you take Zofran (ondansetron) for Nausea and vomiting from chemotherapy

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  • First few hoursHours
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  • Effectiveness
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  • Possible side effects
  • Headache
  • Constipation
  • Fatigue
  • Heartbeat or rhythm changes
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Side effect rates for Zofran (ondansetron)

From 1081 clinical trials of Zofran when taken for nausea and vomiting after surgery/operation (16 mg single dose)
  • Headache
    9%9%
    5%5%
  • Oxygen deficiency
    9%9%
    7%7%
  • Fever
    8%8%
    6%6%
  • Dizziness
    7%7%
    6%6%
  • Gynecologic problems
    7%7%
    6%6%
  • Anxiety
    6%6%
    5%5%
  • Problems urinating
    5%5%
    3%3%
  • Itching
    5%5%
    4%4%
0%
10%
20%
30%
40%
50%
60%
70%
80%
Where we got our data »

The placebo bar shows how common a side effect was for people taking a sugar pill instead of Zofran.

Zofran (ondansetron)
Placebo

People taking Zofran felt side effect more

People taking Zofran felt side effect less

No difference

Risks and Warnings for Zofran (ondansetron)

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    • Higher risk if:
    • Taking antidepressants, lithium, or some migraine medicines with Zofran (ondansetron).

    Serotonin syndrome is a rare but potentially life-threatening condition that's caused by too much serotonin in the brain. Risk of getting serotonin syndrome increases if you take Zofran (ondansetron) with other medications that also affect serotonin, such as antidepressants, lithium, migraine medicines, and St. John's wort. Symptoms include fast heartbeat, sweating, nausea/vomiting, muscle stiffness or spasms, fever, and confusion. Go to the hospital right away if you have symptoms.

Common concerns from people taking Zofran (ondansetron)

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    Nausea and vomiting after surgery