Zurampic

(lesinurad)

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Treats gout.

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Our bottom line

Zurampic (lesinurad) is used to treat gout, but you must take it with either allopurinol or Uloric.

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    $376.95
Quick facts about Zurampic
  • Drug class: Renal
  • Rx status: Prescription only
  • Generic status: No lower cost generic available

Upsides

  • If allopurinol or Uloric alone doesn't work well for your gout, adding Zurampic (lesinurad) can help keep your gout flares under control.
  • Aside from headaches and rare cases of kidney side effects, Zurampic (lesinurad) does not cause many side effects.
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What to expect from Zurampic, on one page

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Downsides

  • Zurampic (lesinurad) can harm your kidneys. Your doctor will test your kidney function before starting Zurampic (lesinurad).
  • You should drink 2 liters of fluid (about 8 cups) throughout the day while taking Zurampic (lesinurad).
  • Taking Zurampic (lesinurad) alone could cause problems with your kidneys. If you stop taking allopurinol or Uloric, stop taking Zurampic (lesinurad).
  • Like other gout medications, gout flares can happen shortly after starting Zurampic (lesinurad) because of a change in your uric acid level. Your doctor may give you other medicines (like colchicine, Indocin, or Naprosyn) to try and prevent flares.
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What to expect from Zurampic, on one page

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How it works

Zurampic (lesinurad) is an antigout medicine. Gout attacks happen because of a buildup of uric acid crystals in the body. Zurampic (lesinurad) works by getting rid of uric acid through your urine.

Quick facts about Zurampic
  • Drug class: Renal
  • Rx status: Prescription only
  • Generic status: No lower cost generic available

Used for

Dosage forms

  • Pill
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Prices and coupons

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What to expect when you take Zurampic (lesinurad) for Gout

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  • First few hoursHours
    First few daysDays
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  • Effectiveness
  • Starts to kick in
    Full effects
  • First few hoursHours
    First few daysDays
    First few weeksWeeks
    First few monthsMonths
  • Possible side effects
  • Headache
  • Flu
  • Heartburn (acid reflux)
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Side effect rates for Zurampic (lesinurad)

From 1027 clinical trials of Zurampic when taken for gout (zurampic 200 mg)
  • Headache
    5%5%
    4%4%
  • Flu
    5%5%
    3%3%
  • Heartburn (acid reflux)
    3%3%
    1%1%
0%
10%
20%
30%
40%
50%
60%
70%
80%
Where we got our data »

The placebo bar shows how common a side effect was for people taking a sugar pill instead of Zurampic.

Zurampic (lesinurad)
Placebo

People taking Zurampic felt side effect more

People taking Zurampic felt side effect less

No difference

Risks and Warnings for Zurampic (lesinurad)

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    • Higher risk if:
    • Taking Zurampic (lesinurad) without a xanthine oxidase inhibitor
    • History of kidney problems
    • History of kidney transplant
    • Dialysis

    While taking Zurampic (lesinurad), people have had kidney failure, especially those who took the medicine alone. Zurampic (lesinurad) should always be used together with a xanthine oxidase inhibitor (like allopurinol or Uloric). If you have symptoms of nausea, vomiting, or pain in your back or upper abdomen, tell your doctor right away.

    This is a black box warning. The FDA requires this warning when there is a significant risk of serious or life-threatening effects that anyone taking the drug should consider.

Means that some groups have a high risk of experiencing this side effect

Common concerns from people taking Zurampic (lesinurad)

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Food
  • You should not take Zurampic (lesinurad) if you have tumor lysis syndrome (a fast breakdown of cancer cells) or a rare condition that causes too much uric acid in the blood (Lesch Nyhan syndrome).
  • Take Zurampic (lesinurad) with food and water. It is important to stay hydrated while on this medication.
Kidneys and liver
  • Aside from headaches and rare cases of kidney side effects, Zurampic (lesinurad) does not cause many side effects.
  • Zurampic (lesinurad) can harm your kidneys. Your doctor will test your kidney function before starting Zurampic (lesinurad).